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Only acknowledged in 1988, Choline is a relatively new nutrient on the scene. [1] Though it’s a recent discovery, it’s been tagged as an essential nutrient. [2] Moreover, even though it’s produced naturally in the body, its amount is too little to be effective. Thus, making Choline quite a popular ingredient in the best supplements.

It is often grouped with vitamin B complex as it shares similarities regarding how it impacts health. Generally, studies show that it affects DNA synthesis, cell maintenance, nervous system functioning, and metabolism. It may also help in healthy brain development and muscle movements.

Additionally, a 2018 study concluded that higher intakes of Choline might reduce the risk of ischemic stroke. [3] Also, it may aid in improving cognitive function based on research. A 2019 observational study shows that insufficient choline levels, along with vitamin C and zinc, are attributed to inferior working memory in older men. [4]

Furthermore, the supplementation of choline may reduce the likelihood of pregnancy complications, according to a 2013 study. [5] However, since this is a newly discovered nutrient, the best choline supplement benefits need further research to assess its impact conclusively.

Quick Summary:

Most Choline Content Per Serving: Solgar Phosphatidyl Choline

Most Affordable Choline Supplement: Natural Factors Phosphatidyl Choline

Best Added Value: Nature’s Way Choline & Inositol

BrandCholine Content Per ServingPrice/Number of CapsulesDosage Recommendation
Double Wood Supplements CDP Choline300 mg~$20/60

Take 1 capsule in the morning
Solgar Phosphatidyl Choline840 mg
~$17/100Take 2 softgels daily, preferably with a meal
Nature’s Way Choline & Inositol500 mg~$18/100Take 2 capsules daily, preferably with food
Jarrow Formulas, Citicoline, CDP Choline250 mg
Take 1 capsule up to two times daily with food
Natural Factors Phosphatidyl Choline420 mg~$14/90Take 1 softgel three times per day

Best Choline Supplements

Double Wood Supplements CDP Choline

Double Wood Supplements CDP Choline Review

300 mg




Take 1 capsule in the morning


  • Gluten-free
  • Non-GMO
  • Free of soy


  • A few users reported feeling some side effects
  • Contains gelatin (capsules)

A trusted brand, Double Wood Supplements, is known for manufacturing excellent products for different uses and conditions. Its Choline capsules are no different as a third-party source tested them for quality, purity, and potency. Additionally, to prevent ambiguity, the brand also releases a Certificate of Analysis for each of its supplements.

Moreover, the brand mentioned avoiding exceeding a dosage of 1200 mg. A conservative approach must also be taken when consuming Choline supplements. This product also aims to support cognitive function that may result in better working memory and improved problem-solving ability.

On top of that, it might also assist in boosting the ability to learn new information, retain details, and recall memories swiftly. It also helps raise or maintain healthy Choline levels in the body, which may improve your mood.

As for user feedback, the consensus is also positive. On Amazon, there are more than 1,900 ratings, and a fantastic 71% gave this supplement a 5-star grade. Many users also mentioned that taking this Choline capsule helped them with mental clarity and boosted their cognitive abilities. They also said it gave them “alertness” and uplifted their overall moods. However, some users experienced side effects like lack of focus and headaches.

Solgar Phosphatidyl Choline

Solgar Phosphatidyl Choline Review

840 mg




Take 2 softgels daily, preferably with a meal


  • Affordable
  • Gluten-free
  • No artificial flavor, color, and preservatives
  • Free of wheat, sugar sodium, yeast, dairy, and sweeteners


  • Contains soy ingredients
  • A few users experienced some side effects

Solgar’s Choline supplements are also made from ingredients that guarantee quality. As a player in the industry for the past 75 years, it’s no surprise that Solgar products are highly-regarded as superb. Even its packaging is also made of excellent materials that protect the capsules from light, moisture, and heat. This prevents them from sticking together, which can be quite troublesome.

This specific supplement by the brand aims also to encourage the body to produce an important neurotransmitter called acetylcholine. Additionally, taking this promotes healthy cognitive functions.

Based on over 1,500 ratings, the user feedback is also mostly positive. Many users said it also helps them increase their focus and mental clarity. Moreover, some mentioned that this Choline supplement was recommended to them to aid in treating their fatty liver. Although, a few noted experiencing side effects like stomach pain. Others also didn’t like the size of the capsules as they were hard to swallow.

Nature’s Way Choline & Inositol

Nature’s Way Choline & Inositol Review

500 mg




Take 2 capsules daily, preferably with food


  • Gluten-free
  • No artificial colors, flavors, or preservatives
  • Free of salt, wheat, dairy products, and yeast-derived ingredients


  • Contains gelatin (capsule)
  • A few reported side effects

Nature’s Way’s Choline supplement was also carefully tested and produced using superior standards to ensure quality. Additionally, the bottle is made from 97% recycled materials, which separates the brand from others.

Aside from Choline, this product also contains another main ingredient called Inositol. Often referred to as Vitamin B8, Inositol is a type of sugar that plays a major role in supporting important functions in the body, like influencing the actions of insulin. [6] It’s also a vital component of cell membranes. Combining the two substances in this supplement also helps improve the health benefits as they complement each other.

The feedback is mostly composed of positive ratings and reviews. Many users also praise the quality of the products as it helps them develop a clearer mind. Some also mentioned that they’re using this Choline supplement to fix their fatty liver. Nonetheless, a few experienced some side effects.

Jarrow Formulas, Citicoline, CDP Choline

Jarrow Formulas, Citicoline, CDP Choline Review

250 mg




Take 1 capsule up to two times daily with food


  • Dairy-free
  • Gluten-free
  • No soybean, egg, peanuts/tree nuts, wheat, and fish/shellfish


  • A bit pricier compared to others
  • It contains bovine gelatin capsules
  • Some users reported feeling side effects

As a leading brand in the industry, Jarrow Formulas is no stranger to producing products made of high-quality and effective formulations. Citicoline, a naturally-occurring median involved in phosphatidylcholine synthesis, is also found in this CDP Choline supplement.

What’s more, it can help in promoting healthy brain energy metabolism. It also stimulates the production of cognitive neurotransmitters such as dopamine. Further, it can support the attention performance of adults.

There are over 1,000 ratings for this Choline supplement in iHerb alone, and the feedback is full of compliments except for a select few who said they experienced some side effects. Anyhow, many are happy as it helps improve their cognitive abilities. It also lifts their “brain fog” and allows them to focus more throughout the day. 

Natural Factors Phosphatidyl Choline

Natural Factors Phosphatidyl Choline Review


420 mg




Take 1 softgel three times per day


  • Non-GMO
  • Dairy-free and gluten-free
  • Free of artificial colors, preservatives, and sweeteners
  • Affordable


  • Contain soy and gelatin
  • The size of the softgels may be too big for some

As one of the largest manufacturers of supplements in America, Natural Factors is committed to producing high-quality products. This supplement also aims to provide benefits for promoting healthy liver functions and helping with the digestion of fats. Moreover, it can improve one’s concentration and memory. It may also allow for cellular support throughout the body.

The feedback for this Choline supplement is mostly positive as many users are also happy with the benefits. Many also use it to improve their liver health or treat current fatty liver issues. Plenty of them also mentioned that taking it enhances their memory and boosts their brain wellness.

Frequently Asked Questions:

What is the best form of Choline to take?

Choline is a vital nutrient that the body cannot produce enough of on its own. Therefore, supplementation is necessary. Furthermore, it makes the most sense to take the best Choline supplements for a consistent daily dose.

Those products may contain different forms of Choline, such as lecithin, choline bitartrate, and phosphatidylcholine. However, not enough data is available to comprehensively compare the differences in their bioavailability. [7]

Of course, you can also consume foods high in this nutrient, like proteins and whole grains. However, If you need the same amount of dose daily, this might not be ideal. It’s also best to consult a doctor about the best form of Choline you need to take.

Who should take Choline supplements?

Most people do not need to worry about their daily Choline intake. Nonetheless, some are advised by healthcare professionals to consume Choline in one form or another to help with conditions like having a fatty liver or improving cognitive functions.

What are the side effects of Choline supplements?

Too much Choline intake can result in side effects. Some users may also experience sweating, nausea, drop in blood pressure, vomiting, and diarrhea. [8] Either follow the brand’s dosage recommendation or consult your doctor first to reduce the risks. 

How much Choline is needed to reverse fatty liver?

Studies show that sufficient Choline intake may also help treat a fatty liver. [9] In addition, user feedback shows that it helps reduce symptoms of liver-related issues. However, the exact dosage needed to reverse a fatty liver needs more research. It might also even depend on the severity of the diagnosis.

Bottomline: Best Choline Supplements

Choline is a vitamin-like nutrient that is essential to provide support for several body functions. It also provides many benefits like improving cognitive functions and treating liver-related illnesses. In this article, you’ll find the best Choline supplements with different price points and dosage recommendations. Hopefully, this helps you in making a decision!

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional. We have assembled this article through in-depth research based on the information available at the date of publishing.  We may receive a small commission for purchases you make through our links, but this comes at NO extra cost to you. This commission allows us to continue doing what we love through Health Plugged, which is delivering evidence-based health information to our readers worldwide.

Editorial References And Fact-Checking

  • Zeisel, S. H., & da Costa, K. A. (2009, November). Choline: an essential nutrient for public health. Nutrition Reviews, 67(11), 615–623. https://doi.org/10.1111/j.1753-4887.2009.00246.x
  • Zeisel, S. H., & da Costa, K. A. (2009). Choline: an essential nutrient for public health. Nutrition reviews67(11), 615–623. https://doi.org/10.1111/j.1753-4887.2009.00246.x
  • Millard, H. R., Musani, S. K., Dibaba, D. T., Talegawkar, S. A., Taylor, H. A., Tucker, K. L., & Bidulescu, A. (2018). Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study. European journal of nutrition57(1), 51–60. https://doi.org/10.1007/s00394-016-1296-8
  • Goldberg, E., Kindilien, S., Roberts, M., & Cohen, D. (2019). Working Memory and Inadequate Micronutrient Consumption in Healthy Seniors. Journal of nutrition in gerontology and geriatrics38(3), 247–261. https://doi.org/10.1080/21551197.2019.1627269
  • Jiang, X., Bar, H. Y., Yan, J., Jones, S., Brannon, P. M., West, A. A., Perry, C. A., Ganti, A., Pressman, E., Devapatla, S., Vermeylen, F., Wells, M. T., & Caudill, M. A. (2012, November 29). A higher maternal choline intake among third‐trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms‐like tyrosine kinase‐1 (sFLT1). The FASEB Journal, 27(3), 1245–1253. https://doi.org/10.1096/fj.12-221648
  • Larner J. (2002). D-chiro-inositol–its functional role in insulin action and its deficit in insulin resistance. International journal of experimental diabetes research3(1), 47–60. https://doi.org/10.1080/15604280212528
  • Office of Dietary Supplements – Choline. (n.d.). Retrieved September 16, 2022, from https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/
  • Bernhard, W., Lange, R., Graepler-Mainka, U., Engel, C., Machann, J., Hund, V., Shunova, A., Hector, A., & Riethmüller, J. (2019). Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact. Nutrients11(3), 656. https://doi.org/10.3390/nu11030656


  • Beatriz Galang

    Beatriz is an exceptional freelance medical writer. This is a craft she has been honing since her university years. Beatriz also has experience writing content in the health and wellness field, which she is extremely passionate about. She aims to help her readers understand their health and wellness deeper and make better health-related decisions. LinkedIn


Beatriz is an exceptional freelance medical writer. This is a craft she has been honing since her university years. Beatriz also has experience writing content in the health and wellness field, which she is extremely passionate about. She aims to help her readers understand their health and wellness deeper and make better health-related decisions. LinkedIn