Cissus Quadrangularis is a plant that is commonly found in parts of Asia, Africa, and the Middle East. It belongs to the grape family and is revered in traditional medicine to treat a wide variety of illnesses. [1] Today, Cissus Quadrangularis is a popular ingredient in some of the best herbal supplements available.

This plant contains high contents of Vitamin C and a multitude of antioxidant compounds such as tannins and carotenoids. [2] Additionally, it has pain-relieving properties that have helped treat joint pain and menstrual cramps since ancient times. 

Aside from that, Cissus Quadrangularis is cited for its bodybuilding benefits. One study had 28 men consume 3,200 mg of the plant extract, and it significantly reduced joint pain resulting from exercise. [3] The plant is also used as a weight-loss supplement, and according to one study, 72 participants took 300 mg of Cissus, which resulted in reduced body fat and weight, waist size, LDL, and blood sugar. [4

It also helps treat bone fractures, diabetes, and hemorrhoids. Based on a 6-week study, 9 people took 500 mg of Cissus Quadrangularis, which helped treat their fractured jawbones. Moreover, the plant seemed to reduce swelling and pain. [5]

Let’s explore some of the best Cissus Quadrangularis supplements and brands on the market!


Quick Summary

Best Cissus Quadrangularis Powder: Bulk Supplements Cissus Quadrangularis 

Most Affordable Capsule: Toniiq Cissus Quadrangularis

Most Cissus Quadrangularis Content: Absonutrix Cissus Quadrangularis Xtreme


BrandCissus Quadrangularis Content per ServingPrice/Number of CapsulesDosage Recommendation
Double Wood Cissus Quadrangularis Extract1000 mg~$30/150
2 capsules daily
Bulk Supplements Cissus Quadrangularis Extract500 mg
~$17/250⅕ tsp. once or twice daily
Primaforce Cissus1000 mg~$26/120
2 capsules twice daily, 30 minutes before a meal
Absonutrix Cissus Quadrangularis Xtreme1600 mg
~$22.50/120
2 capsules daily with breakfast and dinner
Toniiq Cissus Quadrangularis1200 mg
~$18/1202 capsules daily

Best Cissus Quadrangularis Supplements

Double Wood Cissus Quadrangularis Extract

Double Wood Cissus Quadrangularis Extract
CISSUS QUADRANGULARIS CONTENT PER SERVING:

1000 mg

PRICE/NUMBER OF CAPSULES:

~$30/150

DOSAGE RECOMMENDATION:

2 capsules daily

Pros

  • Non-GMO
  • Gluten-free
  • Soy Free

Cons

  • Some side effects were reported

Made by a very trusted brand, this supplement went through third-party testing to ensure the quality and potency of the product. Also, a Certificate of Analysis was awarded based on the testing. In the spirit of transparency, all related documents are even on the company website. The product is manufactured in a GMP-certified facility to ensure industry standards are met.

The supplement aims to support cartilage health as Cissus may aid in stimulating collagen production to help with joint pain. Additionally, it may strengthen the bones by supporting bone density.

Based on over a thousand reviews, the consensus is positive. Many users are happy with the changes resulting from consuming the supplements. Most reviews are about how the supplement helped them be free from pain resulting from diverse issues such as surgery, arthritis, stiff ligaments, and much more. Moreover, some used it for weight loss with a positive result. However, as with other supplements, some users reported side effects. Insomnia, headaches, and joint inflammation are some of the things they experienced.


Bulk Supplements Cissus Quadrangularis Extract

Bulk Supplements Cissus Quadrangularis Extract
CISSUS QUADRANGULARIS CONTENT PER SERVING:

500 mg

PRICE/SIZE:

~$17/250

DOSAGE RECOMMENDATION:

⅕ tsp. once or twice daily

Pros

  • Easy to consume
  • No sugar, soy, dairy, gluten
  • No additives 

Cons

  • Contains gelatin

This supplement is in powder form as opposed to normal capsules. It’s third-party tested, so it’s safe to consume, and the quality is ensured. Additionally, it’s lab-verified, which means the procedure met industry standards for the equipment, samples, and data. It aims to support bone health, strengthen the immune system, maintain healthy cholesterol levels, aid in weight loss, and so much more. You can get this supplement in different sizes depending on your needs.

Many users are happy with the health benefits that come with consuming this supplement. They like the taste and how versatile it is since it can be mixed with the liquid of your choice. Furthermore, a lot of them said it freed them from the pain they were experiencing because of their medical conditions. A user also noted an increase in energy levels and reduced appetite.


Primaforce Cissus

Primaforce Ciss
CISSUS QUADRANGULARIS CONTENT PER SERVING:

1000 mg

PRICE/NUMBER OF CAPSULES:

~$26/120

DOSAGE RECOMMENDATION:  

2 capsules twice daily, 30 minutes before a meal

Pros

  • Produced in GMP-facility
  • No artificial color
  • Free of soy and gluten

Cons

  • Lack of effectiveness for some users

This supplement is lab-tested for quality and safety assurance. According to the brand, it’s a dietary supplement consisting of Cissus Quadrangularis that aims to support weight loss. Additionally, it can reduce inflammation, improve bone and joint health, and strengthen immunity.

In general, the product users are happy with the benefits. Users report experiencing pain relief and bone healing due to consuming this supplement. According to them, it also helps suppress appetite, which is great for weight loss. Most of them, though, are very happy with how this aids them in removing their joint pain.


Absonutrix Cissus Quadrangularis Xtreme

Absonutrix Xtreme
CISSUS QUADRANGULARIS CONTENT PER SERVING:

1600 mg

PRICE/NUMBER OF CAPSULES:

~$22.50/120

DOSAGE RECOMMENDATION:

2 capsules daily with breakfast and dinner

Pros

  • Non-GMO
  • Gluten-free
  • Vegetable capsules

Cons

  • Packaging problems
  • Contains gelatin

This supplement is made by a brand that uses natural and high-quality ingredients based on effective and tested formulas. Additionally, its products are made following GMP standards and are GMP certified. This product aims to support joint and bone health, as well as help users manage pain.

Based on hundreds of reviews on Amazon, this Cissus Quadrangularis supplement is well-received by most users. Many of them have contributed their relief from pain to this product. Also, some said it affects their metabolism, which is great for weight loss. However, dampened the experience of some users.


Toniiq Cissus Quadrangularis

Toniiq Cissus Quadrangularis
CISSUS QUADRANGULARIS CONTENT PER SERVING:

1200 mg

PRICE/NUMBER OF CAPSULES:

~$18/120

DOSAGE RECOMMENDATION:

2 capsules daily

Pros

  • Vegetable capsules
  • GMP-certified
  • NSF-approved facility
  • Affordable

Cons

  • Some users experienced no effect

Toniiq assures that each batch of this supplement is tested by the brand and a third-party independent laboratory. This results in quality and potent products. Each serving (2 capsules) contains over 120 mg of ketosteroids, giving Cissus its bioactive properties.

Many users are happy with this supplement as it does aid in their weight loss regimes. They noticed the loss of body fats and reduced appetite. Moreover, a lot experienced relief from body pain caused by their medical conditions. However, someone noted gastrointestinal problems and pain. There are also a few users who did not experience the benefits listed by the brand.


How to Choose the Best Cissus Quadrangularis Supplements

Here are some things to keep in mind when choosing the best Cissus Quadrangularis supplement for yourself:-

  • Third-party lab testing: This ensures that a third party has certified and assured the quality and safety of the supplement you’re consuming. Third-party lab-tests typically also ensure that the supplement ingredients meet that stated on the label. You can check the results of these tests on the Certificate of Analysis, which is usually displayed on the brand’s website.
  • Quality control: Ensure you purchase supplements from a reputable brand. Also, if the supplement is manufactured in a GMP-certified facility, this is typically a good sign that points toward quality.
  • User reviews: User reviews are one of the most valuable and honest sources of information you have access to. Look out for comments on areas like shipping duration and handling, expiry dates, state of product upon arrival, taste, texture, and ease of consumption.
  • Formulation: Do you prefer adding your supplement to a shake? Perhaps, you hate swallowing tablets. Your preferences will determine which supplement form suits your needs and lifestyle better.

Possible Side Effects of Cissus Quadrangularis Supplements

Generally, the consumption of Cissus Quadrangularis is safe, and the risks of side effects are minimal. Nonetheless, some users reported experiencing dry mouth, diarrhea, headaches, intestinal gas, and insomnia. [6]

With limited research involving pregnant and nursing women, it’s advised to either avoid supplements containing the plant extract or consult a doctor first. Additionally, if you’re taking other medications, be cautious and talk to a healthcare professional first to avoid risky interference.

Frequently Asked Questions:

Does Cissus reduce weight?

Yes, it does. According to studies, it does help promote weight loss. One study showed that a combination of Cissus Quadrangularis and Irvingia Gabonensis resulted in weight loss and positively impacted metabolic syndrome. [7] Moreover, users of the best Cissus Quadrangularis noticed reduced appetite and shredding of body fats. 

When should I take Cissus?

That would depend on the brand recommendation. You can also consult a healthcare professional, especially if you’re taking other medications at specific times.

How long does it take for Cissus to work?

Everyone’s system reacts differently when it comes to supplements. Some might see results faster, others might have to wait a little longer to see the effects, and some might not even experience the promised benefits.

Is Cissus Quadrangularis anti-inflammatory?

A study involving rats with arthritis shows that the plant effectively decreases inflammation. [8] More research involving humans needs to be conducted. Although, based on user reviews, Cissus Quadrangularis supplements helped them decrease inflammation.

Bottomline: Best Cissus Quadrangularis Supplements

Cissus Quadrangularis is a plant that contains an amazing nutrient profile that produces many health benefits. It has become a popular ingredient in supplements, making it very accessible to customers. This article contains some of the best Cissus Quadrangularis supplements available in the market based on brand and product quality. 

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional. We have assembled this article through in-depth research based on the information available at the date of publishing.  We may receive a small commission for purchases you make through our links, but this comes at no extra cost to you. This commission allows us to continue doing what we love through Health Plugged, which is delivering evidence-based health information to our readers worldwide.

Editorial References And Fact-Checking

  • Brahmkshatriya, H. R., Shah, K. A., Ananthkumar, G. B., & Brahmkshatriya, M. H. (2015). Clinical evaluation of Cissus quadrangularis as osteogenic agent in maxillofacial fracture: A pilot study. Ayu36(2), 169–173. https://doi.org/10.4103/0974-8520.175542
  • Jainu, M., & Devi, C. S. (2005). In Vitro. andIn Vivo. Evaluation of Free-Radical Scavenging Potential ofCissus quadrangularis. Pharmaceutical Biology, 43(9), 773–779. https://doi.org/10.1080/13880200500406636
  • Bloomer, R. J., Farney, T. M., McCarthy, C. G., & Lee, S. R. (2013). Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study. The Physician and sportsmedicine41(3), 29–35. https://doi.org/10.3810/psm.2013.09.2021
  • Oben, J. E., Ngondi, J. L., Momo, C. N., Agbor, G. A., & Sobgui, C. S. (2008). The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids in health and disease7, 12. https://doi.org/10.1186/1476-511X-7-12
  • Brahmkshatriya, H. R., Shah, K. A., Ananthkumar, G. B., & Brahmkshatriya, M. H. (2015). Clinical evaluation of Cissus quadrangularis as osteogenic agent in maxillofacial fracture: A pilot study. Ayu36(2), 169–173. https://doi.org/10.4103/0974-8520.175542
  • Oben, J., Kuate, D., Agbor, G., Momo, C., & Talla, X. (2006). The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids in health and disease5, 24. https://doi.org/10.1186/1476-511X-5-24

Beatriz is an exceptional freelance medical writer. This is a craft she has been honing since her university years. Beatriz also has experience writing content in the health and wellness field, which she is extremely passionate about. She aims to help her readers understand their health and wellness deeper and make better health-related decisions. LinkedIn