We’ve shortlisted products we think may be helpful for our readers. If you purchase any product through the links on our page, we may receive a small commission at no extra cost to you.

You might have heard of hyaluronic acid when browsing through blogs and websites about skincare. But what is it? Well, hyaluronic acid is a substance produced naturally by the body, and most of it can be found in your skin, eyes, and joints. It provides lubrication and hydration by retaining water. Its artificial forms are used in the best hyaluronic acid supplements.

Hyaluronic acid has many health and wellness benefits that have made it very popular amongst users, especially older ones. One of its main functions is to promote healthier skin. Moreover, hyaluronic acid supplements increase skin moisture in adults. [1] Hyaluronic eye drops may also help treat dry eyes since a study showed they increased tear production significantly. [2]

What’s more, it can be used to reduce joint pain, speed up wound healing, promote bone strength, and so much more. Additionally, hyaluronic acid supplements have many forms aside from capsules, as it’s also found in serums, injections, and eye drops. 

In this article, we’ll explore some of the best hyaluronic acid supplements available on the market!

Quick Summary

Best Hyaluronic Acid Powder: Micro Ingredients Pure Hyaluronic Acid

Most Added Value: California Gold Nutrition Hyaluronic Acid Complex

Best In Bioavailability: Pure Encapsulations Hyaluronic Acid

BrandHyaluronic Acid Per ServingPrice/Number of Capsules/GramsDosage Recommendation
Micro Ingredients Pure Hyaluronic Acid100 mg ~$23/30 grams

1 full scoop mixed into a drink. Consume 2x daily
Pure Encapsulations Hyaluronic Acid70 mg
  ~$103/180Take 1 to 2 capsules daily, in divided doses, with or between meals
California Gold Nutrition Hyaluronic Acid Complex100 mg~$17/601 capsule daily with or without food

NeoCell Hyaluronic Acid100 mg
2 capsules daily
Bulk Supplements Sodium Hyaluronate141 mg
~$20/10 gramsTake 150 mg once or twice daily

Best Hyaluronic Acid Supplements

Micro Ingredients Pure Hyaluronic Acid

Micro Ingredients Pure Hyaluronic Acid Review

100 mg


~$23/30 grams


1 full scoop mixed into a drink. Consume 2x daily


  • Gluten-free
  • No fillers
  • Water soluble 
  • No preservatives and additives


  • Dissolving issues
  • Packaging problems

As one of the most trusted brands in the industry, Micro Ingredients’ hyaluronic acid is formulated with quality and pure cosmetic ingredients. Moreover, it contains a high molecular weight to maximize the benefits. Its packaging is also of quality as it uses UV protection to maintain freshness and avoid oxidation of the powder.

It aims to hydrate dry and aging skin effectively. Additionally, it may result in users looking younger due to its effect on reducing wrinkles. What it does is aid in locking in the moisture and increasing the skin’s elasticity.

Based on thousands of reviews, users seem content with the product. A lot of them are happy as it seems to help with their dry skin. Also, some said it relieved them from joint pain. However, some experienced some issues with dissolving the powder.

Regarding its application, a lot of users actually used the powder to make their own serum which was very helpful for them. So, aside from mixing it with your drink, you can also use it in other ways that may benefit you.

Pure Encapsulations Hyaluronic Acid

Pure Encapsulations Hyaluronic Acid Review

70 mg




Take 1 to 2 capsules daily, in divided doses, with or between meals


  • Hypoallergenic
  • No artificial additives
  • Non-GMO
  • Free from wheat, eggs, and gluten


  • Very expensive

Pure Encapsulations is known in the industry for its unique formulas to maximize the quality of its products. As such, its Hyaluronic Acid supplement is no exemption. This supplement is formulated for maximum absorption and bioavailability by using HyaMax® sodium hyaluronate instead of the natural form of the substance. 

Moreover, this design helps with the fermentation process, which creates a form of hyaluronic acid that’s absorbed by the skin, joints, and connective tissues. This product provides the necessary substance to support shock absorption and adequate lubrication. Additionally, it may also lead to a reduction in inflammatory symptoms and joint pain.

Many users seem quite happy with the benefits they experienced by taking this supplement. Some said it was effective for alleviating pain, while others mentioned it helped treat their dry skin. Also, they like that the capsules are easy to swallow compared to others. However, the biggest issue is the expensive price tag.

California Gold Nutrition Hyaluronic Acid Complex

California Gold Nutrition Hyaluronic Acid Complex Review

100 mg




1 capsule daily with or without food


  • Non-GMO
  • Gluten-free
  • No soy
  • Vegetarian and vegan-friendly


  • Very expensive Some users noted that it was ineffective for them
  • Very expensive A few side effects

Hyaluronic Supplement by California Gold has undergone third-party auditing to ensure quality, purity, and potency. Furthermore, it has additional ingredients such as L-Proline, French Maritime Pine Bark Extract, and French Grape Seed Extract to add more nutritional value. It also aims to supply the body with enough hyaluronic acid to help support healthy skin. Additionally, it may aid in maintaining joint functions. 

Its approval rating from users is quite high, and many are happy with the benefits they receive. The supplement, they said, helped hydrate their skin, while others mentioned that it reduced their pain. Some, however, claimed that it led to side effects.

NeoCell Hyaluronic Acid

NeoCell Hyaluronic Acid Review

100 mg




2 capsules daily


  • Gluten-free
  • Non-GMO
  • No artificial flavors
  • Free from soy, lactose, and wheat


  • Quite pricey

NeoCell is at the forefront of the industry when it comes to providing solutions to promote vital collagen health. What’s more, its products are manufactured with food-grade raw materials to ensure quality and safety. This supplement contains the most bioavailable form of the substance for better absorption, according to the company.

Additionally, NeoCell’s formula is clinically tested with positive results as it showed that it increased skin hydration. Aside from that, it may also reduce wrinkles and lubricate the surface of the eyes. Many users praised the high quality of this supplement, stating that it has a significant positive impact on their skin. But, some mentioned that it was ineffective for them.

Bulk Supplements Sodium Hyaluronate

Bulk Supplements Sodium Hyaluronate Review

141 mg


~$20/10 grams


Take 150 mg once or twice daily


  • Gluten-free and soy-free
  • No sugar, yeast, or dairy
  • Free from additives


  • Some users experienced side effects

Just like other Bulk Supplements products, this Hyaluronic Powder went through inspections and lab verifications to guarantee its quality and safety. Additionally, a third-party organization tested this supplement. According to the brand, it aims to support the joints and maintain healthy skin. It may also benefit eye health, digestive functions, and overall wellness.

Based on thousands of reviews, the consensus is positive. Many users are content with its health benefits, such as improving their skin quality and reducing their pain. Moreover, they mentioned that it was easily dissolved, and its option for different sizes helps a lot since they can get one for long-term use.

How to Pick the Best Hyaluronic Supplement

When picking a suitable hyaluronic supplement, here are some things to keep in mind:-

  • Type of supplement: Hyaluronic supplements come in powder and tablet/capsule form. Capsules are convenient for those who don’t mind swallowing them daily, while powder supplements may be better suited for those who dislike swallowing capsules. You’d typically have to mix a powder supplement with your favorite beverage or smoothie.
  • Product quality: Whenever possible, perform prior research on the company selling the supplement. Read previous user reviews on the quality of the product, and ensure that you purchase only from established brands. Third-party testing is also useful for ensuring that the product’s quality meets all the necessary standards.
  • Presence of allergens: If you have any specific allergies, even in terms of common food items like nuts, soy, or wheat, it’s best to check that the product does not contain that allergen and that it is not packaged or manufactured in a facility that handles other products containing the allergen.

Frequently Asked Questions:

Do Hyaluronic Acid Supplements Work?

According to scientific studies and user feedback, yes, they do work. Although, keep in mind that even the best hyaluronic acid supplements may not work for others. It will depend on each user and how their body reacts.

Are Hyaluronic Acid Supplements Safe?

In general, yes, they are safe to use. [3]  Moreover, the substance is naturally produced by the boy making allergic reactions quite rare. However, some studies showed that hyaluronic injections might increase the risks of experiencing side effects due to the procedure. [4] [5]

Due to the lack of current studies, pregnant and nursing women are advised to take more precautions to reduce the risks.

How Much Hyaluronic Acid Supplement Should I Take?

There is no universal agreement or consensus on how much a user should take. Nonetheless, some studies showed that the daily intake should be limited to not more than 240 mg. [6]

In addition, every brand has its own dosage recommendations, which should be followed unless otherwise instructed by your doctor.

Do Hyaluronic Acid Supplements Cause Cancer?

Generally, it’s advised that cancer patients should avoid hyaluronic supplements. Some studies suggest that it may promote cancer cell growth. [7] However, you can also ask your doctor for a better understanding and options.

Bottomline: Best Hyaluronic Supplements

Despite being a natural substance produced by the body, hyaluronic acid is a popular ingredient in health and wellness supplements. The aim is to increase the levels of the substance in the body to maximize the benefits. In this article, you’ll find the best hyaluronic acid supplements available on the market. What’s more, capsules and powder forms are available at different price points, so you know what suits you best.

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional. We have assembled this article through in-depth research based on the information available at the date of publishing.  We may receive a small commission for purchases you make through our links, but this comes at NO extra cost to you. This commission allows us to continue doing what we love through Health Plugged, which is delivering evidence-based health information to our readers worldwide.

Editorial References And Fact-Checking

  • Kawada, C., Yoshida, T., Yoshida, H., Matsuoka, R., Sakamoto, W., Odanaka, W., Sato, T., Yamasaki, T., Kanemitsu, T., Masuda, Y., & Urushibata, O. (2014). Ingested hyaluronan moisturizes dry skin. Nutrition journal13, 70. https://doi.org/10.1186/1475-2891-13-70
  • Yang, Y. J., Lee, W. Y., Kim, Y. J., & Hong, Y. P. (2021, March 1). A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome. International Journal of Environmental Research and Public Health, 18(5), 2383. https://doi.org/10.3390/ijerph18052383
  • Oe, M., Tashiro, T., Yoshida, H., Nishiyama, H., Masuda, Y., Maruyama, K., Koikeda, T., Maruya, R., & Fukui, N. (2016). Oral hyaluronan relieves knee pain: a review. Nutrition journal15, 11. https://doi.org/10.1186/s12937-016-0128-2
  • Lafaille, P., & Benedetto, A. (2010). Fillers: Contraindications, side effects and precautions. Journal of Cutaneous and Aesthetic Surgery, 3(1), 16. https://doi.org/10.4103/0974-2077.63222
  • Adams, M. E., Lussier, A. J., & Peyron, J. G. (2000). A risk-benefit assessment of injections of hyaluronan and its derivatives in the treatment of osteoarthritis of the knee. Drug safety23(2), 115–130. https://doi.org/10.2165/00002018-200023020-00003
  • Itano, N., Zhuo, L., & Kimata, K. (2008). Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression. Cancer science99(9), 1720–1725. https://doi.org/10.1111/j.1349-7006.2008.00885.x

Beatriz is an exceptional freelance medical writer. This is a craft she has been honing since her university years. Beatriz also has experience writing content in the health and wellness field, which she is extremely passionate about. She aims to help her readers understand their health and wellness deeper and make better health-related decisions. LinkedIn