First off, what is L-Serine? It is an amino acid and as such, is a building block for protein. Moreover, it’s considered a non-essential amino acid because the body can produce the substance. However, the body does not produce enough, so an external supply coming from the diet is essential to achieve or maintain the necessary L-Serine levels in the body. Also, the best L-Serine supplements may increase those levels and provide health benefits.

If you’re looking for the best L-serine supplements to try, we’ve got a list of some of the best brands on the market! In this article, we’ll take a look at some of the top L-serine supplements you can get your hands on!


Quick Summary

Best Value For Money Powder L-Serine: Bulk Supplements L-Serine

Most L-Serine Content Per Capsule: Lake Avenue Nutrition L-Serine

Lowest Price: Swanson L-Serine

Value For Money: Double Wood L-Serine


BrandL-Serine Content per ServingPrice/Number of Capsules/GramsDosage Recommendation
Double Wood L-Serine2000 mg~$20/180
4 capsules daily
Micro Ingredients L-Serine2000 mg
  ~$48/500 grams1 scoop daily with or between meals
Bulk Supplements L-Serine2000 mg~$18/100 grams3/4 teaspoon daily


Lake Avenue Nutrition L-Serine900 mg
~$19/120 
1 capsule daily with or without food
Swanson L-Serine500 mg
~$10/60 1 capsule daily
Peak Performance L-Serine Brain Booster500 mg~$22/60 1 capsule daily

Best L-Serine Supplements

Double Wood L-Serine

Double Wood L-Serine Review
L-SERINE CONTENT PER SERVING:

2000 mg

PRICE/NUMBER OF CAPSULES:

~$20/180

DOSAGE RECOMMENDATION:

4 capsules daily

Pros

  • Non-GMO
  • Vegan friendly
  • Free of soy and gluten

Cons

  • Some users felt it was not effective

Double Wood is one of the most trusted supplement brands in the industry. Known for its transparency, this supplement’s process is no exception. It is third-party tested to ensure quality and potency. Moreover, a Certificate of Analysis is provided by the brand and available for public viewing. 

According to the brand, this L-Serine supplement can support neuron health due to the synthesis of various phospholipids. Furthermore, it can be used to stimulate the production of other amino acids, which might also improve sleep.

Each capsule contains 500 mg of L-Serine, and the brand recommends taking 4 capsules daily. Users are happy with the supplement as it improves their sleep without interruptions. Additionally, some also noticed a difference in their cognitive function. However, a few users did not notice any effect.


Micro Ingredients L-Serine

Micro Ingredients L-Serine Review
L-SERINE CONTENT PER SERVING:

2000 mg

PRICE/WEIGHT:

~$48/500 grams

DOSAGE RECOMMENDATION:

1 scoop daily with or between meals

Pros

  • No fillers and additives
  • Free of soy, dairy, gluten, and yeast
  • No GMO’s
  • No preservatives

Cons

  • Quite pricey
  • Unpleasant smell and taste

This L-Serine supplement from Microingredients is in powder form and each serving, which is 1 scoop, is equal to 4 tablets and contains 2000 mg of the substance. It’s also really easy to consume as you can mix the powder into any of your favorite drinks. This powder supplement aims to improve the overall cognitive functions, which include your mood, focus, memory, and concentration.

Even the packaging is well thought of as it preserves the freshness and quality of the supplement by offering UV protection. Regarding the reviews, some users were unhappy with the taste and smell of the powder. However, the majority are content with how this supplement benefits them. Some users experienced better sleep while others had a decrease in tremors resulting from medical conditions. Quite a few also note a memory improvement.


Bulk Supplements L-Serine

Bulk Supplements L-Serine Review
L-SERINE CONTENT PER SERVING:

2000 mg

PRICE/WEIGHT:

~$18/100 grams

DOSAGE RECOMMENDATION:

3/4 teaspoon daily

Pros

  • Easy to consume
  • Affordable
  • Lots of size options

Cons

  • Unpleasant smell

Bulk Supplements is one of the trusted brands known for its quality products, and the L-Serine powder supplements are no exception. There are also many options regarding the size of your choice, from 100 grams up to 25 kilograms. Additionally, this supplement went through third-party testing and is lab-verified to ensure quality, potency, and safety.

The supplement is for supporting brain function, improvement of sleep, aiding healthy mood, helping muscle endurance, and protecting the nervous system. As for users’ experiences, aside from a few who did not like the unpleasant smell, it seems to be well-received. Many consumers are happy with how it helped them with their Alzheimer’s symptoms. Quite a few also noticed an improvement in their memory and focus.


Lake Avenue Nutrition L-Serine

Lake Avenue Nutrition L-Serine Review
L-SERINE CONTENT PER SERVING:

900 mg

PRICE/NUMBER OF CAPSULES:

~$19/120 

DOSAGE RECOMMENDATION:

1 capsule daily with or without food

Pros

  • Veggie capsules
  • Non-GMO
  • No soy or gluten

Cons

  • Not a lot of information

This supplement is made in a third-party GMP facility to ensure the industry standards are met. Each capsule contains 900 mg of L-Serine, which is higher than the average of 500 mg. However, there seems to be a lack of information on this product. But according to user reviews, it provides numerous benefits to their health.

Many of them are happy with how it improved their sleep and cognitive functions, particularly their memory and focus. Additionally, they are delighted with the quality, packaging, and affordability of this supplement.


Swanson L-Serine

swanson l-serine review
L-SERINE CONTENT PER SERVING:

500 mg

PRICE/NUMBER OF CAPSULES:

~$10/60 

DOSAGE RECOMMENDATION:

1 capsule daily

Pros

  • Veggie capsules
  • Very affordable
  • Money back guarantee
  • Non-GMO

Cons

  • May contain fillers

This very affordable supplement was tested for purity and potency to deliver a quality product to the market. Swanson’s formula includes producing the L-Serine substance through fermentation done by theJapan’s Ajinomoto, Amino Science LLC experts. This makes this a pharmaceutical-grade substance with high purity.

The brand aims to help with supporting healthy brain health and cognitive functions with this supplement. Additionally, it may aid in improving the overall nervous system health. According to users, it’s been a great help in alleviating their “brain fog” caused by medical conditions. Some also experienced better sleep as a result of consuming the Swanson L-Serine.


Peak Performance L-Serine Brain Booster

Peak Performance L-Serine Brain Booster
L-SERINE CONTENT PER SERVING:

500 mg

PRICE/NUMBER OF CAPSULES:

~$22/60 

DOSAGE RECOMMENDATION:

1 capsule daily

Pros

  • Non-GMO
  • No artificial processing
  • Made without preservatives, additives, soy, and dairy

Cons

  • A bit pricey

Peak Performance is known for its quality supplements and its remarkable initiative with Vitamin Angels. This L-Serine supplement went through third-party testing to guarantee purity, potency, and safety. It helps maintain good brain functions such as memory, focus, and attention. Additionally, the capsules are designed for easy consumption.

Feedback from users is generally positive, as many said it does as promised by the brand. Many experienced better sleep by taking the pills. Moreover, a lot also saw signs of improvements in her memory and concentration.


What Are The Benefits Of L-Serine Supplements?

Research shows that L-Serine is essential for synthesizing phosphatidylserine, which is an important component of the membrane of brain cells. [1] Additionally, in a study on mammals with brain injuries, L-Serine protected brain tissues and inhibited inflammation, improving the recovery of neurological functions. [2]

Another possible benefit is to help reduce stress as serine is needed to produce a substance called tryptophan which is considered a relaxant. According to a published study, tryptophan may improve hormonal and behavioral disorders caused by stress. [3]

Other possible benefits include improving sleep, boosting the immune system, and fighting diabetes. However, more studies or human trials need to be done to know the extent of said benefits.

How to Choose the Best L-Serine Supplements

Here are some things to have in mind while choosing the most suitable L-serine supplement for yourself.

  • Lab-testing: Third-party lab-testing helps ensure you’re getting a quality product. These third-party tests check for purity and accuracy of the ingredient label. You can review a company’s lab test results via their Certificate of Analysis, which is usually available on their website.
  • Ease of consumption: Some people prefer consuming tablets, while others prefer a powder formulation you can add to smoothies or shakes. L-serine supplements come in both powder and capsule form to suit your needs. If you hate swallowing tablets, go for a powder-form supplement, or opt for a brand with a higher dose per capsule, meaning you’ll have to swallow fewer capsules each time.
  • Ingredients: Try to avoid products containing artificial flavoring or coloring. If you have any specific allergies, be sure to check the ingredients list for anything you may be allergic to. Many supplements no longer include common allergens such as soy, wheat, or dairy.

Possible Side Effects of L-Serine Supplements

In general, the use of L-Serine supplements is safe as deemed by the FDA, with no side effects most of the time. However, there is still limited research regarding the subject, so extra caution and following the dosage recommendation of the brand or healthcare professional is essential.

For example, 20 patients with ALS received a positive response to L-Serine in a clinical study. [4] [5] However, two patients withdrew from the trial as they experienced gastrointestinal side effects. So, each person might develop or react differently to L-Serine supplements.

Additionally, there are limited studies and trials involving pregnant and nursing women. Hence, it would be better to consult a doctor first. It will also help to be cautious if you are taking other medications to avoid harmful drug interactions.

Frequently Asked Questions:

Is L-Serine good for memory?

Yes, due to the synthesis of phosphatidylserine. This benefit can also be backed up by the users of the best L-Serine supplements, as many experienced improved cognitive functions.

Does L-Serine help you sleep?

As mentioned before, it helps produce a substance that can be considered a relaxant that helps users have better sleep.

What foods are high in serine?

There are a lot of foods high in serine which include:

  • Eggs
  • Lentils 
  • Lima beans 
  • Wild fish 
  • Lamb
  • Chicken 
  • Chickpeas 
  • Peanuts
  • Soybeans

Are L-Serine supplements safe? 

In general, yes. Of course, it can’t be ignored that everyone might react differently to L-Serine supplements, even the best ones.

Bottomline: Best L-Serine Supplements

Despite being produced by the body naturally, L-Serine levels need to be maintained by consuming food that contains it or taking the best L-Serine supplements. It provides many health benefits, especially in terms of improving cognitive functions. The supplements are safe to consume but if unsure, you can always consult a doctor.

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional. We have assembled this article through in-depth research based on the information available at the date of publishing.  We may receive a small commission for purchases you make through our links, but this comes at NO extra cost to you. This commission allows us to continue doing what we love through Health Plugged, which is delivering evidence-based health information to our readers worldwide.

Editorial References And Fact-Checking

  • Hirabayashi, Y., & Furuya, S. (2008). Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival. Progress in lipid research47(3), 188–203. https://doi.org/10.1016/j.plipres.2008.01.003
  • Zhai, P. P., Xu, L. H., Yang, J. J., Jiang, Z. L., Zhao, G. W., Sun, L., Wang, G. H., & Li, X. (2015). Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury. Neuropharmacology95, 1–11. https://doi.org/10.1016/j.neuropharm.2015.02.026
  • Gul, S., Saleem, D., Haleem, M. A., & Haleem, D. J. (2019). Inhibition of hormonal and behavioral effects of stress by tryptophan in rats. Nutritional neuroscience22(6), 409–417. https://doi.org/10.1080/1028415X.2017.1395551
  • Levine, T. D., Miller, R. G., Bradley, W. G., Moore, D. H., Saperstein, D. S., Flynn, L. E., Katz, J. S., Forshew, D. A., Metcalf, J. S., Banack, S. A., & Cox, P. A. (2017). Phase I clinical trial of safety of L-serine for ALS patients. Amyotrophic lateral sclerosis & frontotemporal degeneration18(1-2), 107–111. https://doi.org/10.1080/21678421.2016.1221971
  • Bradley, W. G., Miller, R. X., Levine, T. D., Stommel, E. W., & Cox, P. A. (2018). Studies of Environmental Risk Factors in Amyotrophic Lateral Sclerosis (ALS) and a Phase I Clinical Trial of L-Serine. Neurotoxicity research33(1), 192–198. https://doi.org/10.1007/s12640-017-9741-x

Beatriz is an exceptional freelance medical writer. This is a craft she has been honing since her university years. Beatriz also has experience writing content in the health and wellness field, which she is extremely passionate about. She aims to help her readers understand their health and wellness deeper and make better health-related decisions. LinkedIn