Finding the best NAD+ booster supplements on the market can be tough. There’s a lot to consider, from the price and dosage to the ingredients and the brand reputation. But we’ve done the work for you and compiled a list of the best NAD+ booster supplements you can purchase.

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme needed in essential processes in our bodies. However, as we age, our NAD+ levels tend to deplete. Science says that low NAD+ levels may be linked to age-related problems, thus boosting NAD+ through supplementation is believed to have potential anti-aging effects.[1

However, with all the NAD+ boosters available, it’s completely understandable to have a little bit of a dilemma in picking the best one depending on your needs. Well, worry no more because we’ve narrowed down the choices for you. 

Although aging is inevitable, the good news is there are studied supplements that may help support healthy aging.

Check out this list we’ve compiled for the best NAD+ supplements in 2022!


Quick summary:

Best Value for Money: Renue by Science NAD+ Complete Liposomal Capsules

Best NAD+ booster supplement overall: Cymbiotika NMN

Best NMN supplement: Double Woods NMN

Best NR supplement: Tru Niagen


BrandContentPrice/Number of CapsulesDosage Recommended By Brand as Dietary Supplement
Renue by Science125mg NMN, 95mg NAD+, 80mg NR per capsule~$95/90 capsules1 capsule/day
Double Woods125mg NMN capsules~$45/60 capsules2-4 capsules/day
Thorne Research ResveraCelNicotinamide riboside hydrogen malate capsules~$48/60 capsules2-4 capsules/day
Tru Niagen300mg NR capsules ~$47/30 capsules 1 capsule/day
Peak Performance150mg NMN, 150mg Resveratrol~$35/30 capsules1 capsule/day
TruBrain ClockwiseNicotinamide capsules$59/60 capsules2 capsules/day
CymbiotikaNMN+Trans-Resveratrol capsules~$70/60 capsules2 capsules/day

Best NAD+ Booster Supplements in 2022

Renue by Science LIPO NAD+ Complete Liposomal Capsules

Renue by Science LIPO NAD+ Complete Liposomal Capsules Review
CONTENT:

125mg NMN, 95mg NAD+, 80mg NR per capsule

PRICE/NUMBER OF CAPSULES:

~$95/90 capsules

DOSAGE RECOMMENDED BY BRAND:

1 capsule/day

Pros

  • Vegetarian and vegan-friendly, non-GMO
  • Contains NAD+ and its precursors: NMN, NR
  • Good absorption rate/bioavailability
  • Made in an FDA-approved facility

Cons

  • Limited customer reviews available for this specific product

First on our List is the Renue by Science NAD+ Complete Liposome capsule also offers quite a unique approach among the other NAD+ boosters. Besides, with the liposome capsules, the active ingredients (NMN, NR, and NAD+) are encapsulated in a natural phospholipid “bubble” to carry them into the bloodstream without being digested in the stomach.

Moreover, this specialized delivery is said to enhance its bioavailability and nutrient absorption—an obvious advantage of this NAD+ supplement. Although the technology used in liposome capsules requires added manufacturing cost, customer reviews mention that the benefits outweigh the cost. It’s also said to be more bioavailable and effective in increasing NAD+ levels—more bang for the buck!

In addition, Renue by Science offers other forms of NAD+ boosters, including the sublingual NMN and liposomal gels. However, if you’re looking for a unique and cost-effective NAD+ supplement, these complete liposomal capsules might be a good choice.


Double Woods NMN Supplement

Double Woods NMN Supplement Review
CONTENT:

125mg NMN capsules

PRICE/NUMBER OF CAPSULES:

~$45/60 capsules

DOSAGE RECOMMENDED BY BRAND:

2-4 capsules/day 

Pros

  • Gluten Free, Soy Free, Non-GMO
  • Odorless and flavorless; easy to swallow
  • Customers notice improved energy levels after a month or so
  • The NMN in this supplement is fully stabilized and doesn’t need refrigeration

Cons

  • Low content of NMN per capsule (125mg)

Next on our list is the Double Woods NAD+ booster supplement that has pure NMN as its ingredient. Nicotinamide mononucleotide is a form of vitamin B3. Although supplements containing other forms of vitamin B3 like niacin or nicotinic acid have been around for a long time already, NMN supplements have recently emerged as an effective way to boost NAD+ levels in the body, specifically in the liver and muscle tissue. 

Moreover, with a customer rating of 4.6/5 on Amazon, it’s one of the top-rated NAD+ booster supplements in the market. Reviews also mention improved energy, sleep quality, and muscle strength after a few months of taking it. Some also highlighted that they shifted from NR supplements (nicotinamide riboside) to this NMN supplement and noticed that they had far better results and lesser side effects.

It’s also noteworthy that this NMN supplement is third-party tested, which means an independent laboratory is involved in quality checking to ensure safety and purity.


Thorne Research ResveraCel

Thorne Research ResveraCel Review
CONTENT:

Nicotinamide riboside hydrogen malate capsules

PRICE/NUMBER OF CAPSULES:

~$48/60 capsules

DOSAGE RECOMMENDED BY BRAND:

2-4 capsules/day 

Pros

  • Free of gluten, soy, and dairy
  • No artificial flavors
  • Customer reviews mention enhancement in energy levels and sleep quality
  • Nicotinamide riboside supplement with 3 complementary ingredients

Cons

  • May cause side effects based on reviews

A handful of reviews also describe this product as a high-quality nicotinamide riboside (NR) supplement. This can be associated with the fact that it contains a form of NR that is exclusive to Thorne. It also has 3 complimentary ingredients (trans-resveratrol, trimethylglycine, and phospholipid complex from sunflower) known to support your body’s natural aging process and cellular metabolism.

Moreover, it boasts an average rating of 4.7/5 on Amazon and 4.4/5 on iHerb that making it one of the known NAD+ booster supplements in the market. Several reviews also mention that they have been taking this supplement for more than a year already, noticing improved energy levels, mental alertness, as well as an enhanced skin condition.


Tru Niagen Nicotinamide Riboside

Tru Niagen Nicotinamide Riboside Review
CONTENT:

300mg NR capsules

PRICE/NUMBER OF CAPSULES:

~$120/90 capsules 300mg

1 capsule/day

Pros

  • Vegetarian-friendly, no artificial colors/flavors, gluten-free
  • Patented NAD+ booster supplement
  • Published multiple clinical trials for safety and bioavailability
  • Reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs

Cons

  • Packaging is not eco-friendly based on customer feedback
  • May cause a handful of side effects based on customer reviews

If you look up NAD+ booster supplements, Tru Niagen is one of the first ones you might see. Niagen (nicotinamide riboside) is its main ingredient. It’s a novel form of vitamin B3 that is patented and backed by research. NR is also an NAD+ precursor (such as NMN) that is bioavailable and studied to improve NAD+ levels in the body. 

As with other NAD+ supplements, this product claims to improve cellular energy metabolism, cellular repair, vitality, and overall healthy aging. One thing to notice about this supplement is its number of published studies (mostly involving animals), with some still ongoing.

It’s also easily one of the top-rated NAD+ supplements with a 4.5/5 rating from over 3,000 reviews on Amazon. Furthermore, some customers noticed a boost in their energy levels and muscle strength after about 3 months of taking it. A few also mentioned that they feel less tired after hours of workout, which helps significantly in their weight loss journey.

As with other supplements, it also has a mixed bag of results. Some reviews also mentioned that it took a long time for them to notice the benefits. Also, some experienced side effects such as palpitations and stomach pains. These side effects have not been addressed yet and some human clinical trials are still ongoing, so it’s good to consult your doctor beforehand.


Peak Performance NMN+Resveratrol

Peak Performance NMN+Resveratrol Review
CONTENT:

150mg NMN, 150mg Resveratrol

PRICE/NUMBER OF CAPSULES:

~$35/30 capsules

1 capsule/day

Pros

  • Vegan, gluten-free, non-GMO
  • Manufactured and tested in the USA; third-party tested
  • 1+1 donation to a non-profit organization (Vitamin Angels)
  • Potential benefits when NMN is added with resveratrol

Cons

  • 30 capsules only per bottle, no other options
  • Limited customer reviews available

Next on the list is an NMN supplement that took it quite to the next level and added resveratrol. You might also be wondering what is it and if it’s a good combination. Additionally, Resveratrol has a synergistic effect with the NAD+ precursor NMN, and it acts as an accelerator for boosting NAD+ levels.  

Advertised benefits also include cellular repair, muscle strength, and DNA repair among others. Also, something unique about this NAD+ supplement is its non-profit effort. They also have a 1+1 donation program wherein every order, they provide a one-year supply of vitamins to a child at risk of malnutrition through the non-profit organization Vitamin Angels. 


TruBrain Clockwise 

TruBrain Clockwise Review
CONTENT:

Nicotinamide capsules

PRICE/NUMBER OF CAPSULES:

$59/60 capsules

2 capsules/day

Pros

  • Natural ingredients and validated by the National Institutes of Health
  • Improved energy levels and ability to focus according to some reviews
  • Customer feedback mentions improvement in vitality and overall health as long as combined with an active and healthy lifestyle
  • In its clinical trials, the ingredients are proven to increase NAD+ levels by 60%

Cons

  • Limited customer reviews available 

This next NAD+ supplement that also earned a spot on our list is the TruBrain Clockwise. Moreover, with natural ingredients validated by the National Institutes of Health, it’s known to support long-term brain health by raising NAD+ levels within our cells. 

Its natural ingredients also include nicotinamide (a water-soluble form of vitamin B3), zinc, green tea extract, apigenin, rutin, black pepper fruit, alpha-lipoic acid, and caffeine. Furthermore, the recommended dosage is 2 capsules every morning, with or without food.

The brand also reminds us that supplements like Clockwise are just an addition to naturally stimulate NAD production, hence the term supplement. On the other hand, a healthy diet, sleep, and exercise are essential foundational factors in preventing DNA damage and promoting cellular repair.


Cymbiotika NMN

Cymbiotika NMN Review
CONTENT:

NMN+Trans-Resveratrol capsules

PRICE/NUMBER OF CAPSULES:

~$70/60 capsules

2 capsules/day

Pros

  • Cruelty-free, gluten-free, sugar-free, non-GMO, keto-friendly
  • Good combination of ingredients; with 400mg NMN per serving (2 capsules)
  • Easy to swallow and no bad taste based on a review
  • Energy and mood gradually improved after a month (as long as coupled with a healthy lifestyle) according to some customer feedback

Cons

  • Expensive compared to other NAD+ supplements

Last on our list is Cymbiotika NMN. It’s also one of the famous supplements in the NAD+ booster market with a 4.5/5 customer rating on Amazon. Most customers like the formulation as it also has green tea extract, transresveratrol, green coffee bean, and apigenin which are believed to have synergistic effects. These complementary ingredients are also believed to improve cognitive function, immunity, and vitality.

Furthermore, the common concern is the cost as it’s almost double the price of other NAD+ booster brands. However, some reviews say that the premium cost is commensurate with the high-quality ingredients. They believe it’s still worth the price. So, if you’re on a tight budget, this might not work for you. But for those who like added nutrients and antioxidants to complement the effects of NAD boosting (and don’t mind spending a little extra), Cymbiotika NMN might be a good choice.


How to Choose the Best NAD+ Booster Supplement

Now that we’ve covered all the NAD+ booster supplements on our list, you may have realized that not all supplements are created equally. You may or may not have the choice of the NAD+ supplement by now, so, here are crucial factors you may consider when buying. 

Ingredients

The FDA regulates dietary supplements like NAD+ boosters as food, not as drugs. However, many dietary supplements contain ingredients that have certain biological and health effects which may be risky if you have a medical condition or you’re taking a particular medication.[10]

With that said, it’s also important to carefully check the ingredients. It’s also good to consult with your doctor before starting a supplement, especially if you have a medical condition.

Moreover, in our list of best NAD+ booster supplements, we made sure that the products we included contained the right ingredients studied to boost NAD+ production like the form of b-vitamins NR and NMN. 

Transparency and Brand Reputation

In dietary supplements like NAD+ boosters, it’s also ideal that the brands are transparent with the content, benefits, manufacturing information, and other pertinent data. In addition, customers should have full access to this on their website and other places where the product is available.

This is also where a good brand reputation comes in. Subsequently, consumers tend to buy from reputable companies for good reasons. Furthermore, the peace of mind that comes with knowing that the product came from a trustworthy brand is invaluable.

Proven Benefits

As the famous saying goes—if it’s too good to be true, it probably is. So, in buying a dietary supplement, we must be keen on their advertised benefits as some brands tend to overpromise just so they can sell. Thus, the NAD+ supplements we included in our list have proven benefits based on customer reviews and relevant scientific data.

Value for Money

To maximize the benefits of supplements, they are usually recommended for daily intake. Thus, we must consider the best supplement we can sustain without compromising the quality. In our list, we’ve included products with different price points but made sure that all of them are of high quality and offer good value for money.

Precautions and Side Effects

NAD+ supplements are generally safe for most people. However, most brands indicate that pregnant, nursing, and people under the age of 18 should avoid taking this supplement. Most clinical trials of the main ingredients (NMN and NR) also involve animals. Human clinical trials demonstrating its safety and bioavailability are also available, with some still ongoing.

So far, the human studies performed have shown it to be safe and non-toxic. Listed side effects are rare, but itchiness, dizziness, sweating, and nausea have been noted in a few cases. It is also advised to immediately discontinue use if you experience any adverse or allergic reaction.[2][4]

FAQs

Do NAD+ supplements work?

Based on clinical trials, NAD+ supplements are orally bioavailable. It means it can be absorbed and be useful when introduced to the body and it will most likely increase your NAD+ levels. The anti-aging benefits of NAD+ boosting have been demonstrated in extensive clinical trials involving mice. [11

In human clinical trials available, boosting NAD+ by supplementation is proven safe and increased the levels of NAD+. A study also showed that supplementation may lead to significant improvement in amyotrophic lateral sclerosis (ALS) and anti-inflammatory effects.[12][13]

How much NAD+ should I take?

Most NAD+ booster brands recommend taking 250-500mg per day. According to studies, this dose can provide the needed amount to stimulate NAD+ production and increase NAD levels.

How long do NAD+ Booster Supplements take to work?

One clinical study showed that it will take approximately 6-8 weeks for an NAD+ supplement to effectively increase the NAD+ levels in the bloodstream. However, it will slightly vary on the dose, main ingredient, and complementary ingredients. But for reference, most reviews mention about 4-12 weeks for them to notice significant benefits.

What is the difference between NMN and NAD+? 

NAD+ is an essential coenzyme involved in DNA repair, activation of the longevity enzymes called sirtuin, cell metabolism, and energy production. You might have heard the term Adenosine triphosphate (ATP) in your science lessons. Yes, it’s the molecule that provides energy for many processes in our cells, and NAD+ (together with NADH) is a vital part of ATP production.

However, you might wonder why the main ingredients of NAD+ supplements are always the NAD+ precursors like nicotinamide mononucleotide (NMN).

Why can’t we just take NAD? Well, science says that NAD+ in supplemental form has very poor bioavailability, meaning it doesn’t really increase NAD levels in the body. NMN supplement is studied to be much more bioavailable, and after it enters the body, it becomes NAD+ through a series of chemical reactions.

Bottomline: Best NAD+ Booster Supplements

While anti-aging supplements like NAD+ boosters don’t promise the miraculous effects of the fabled fountain of youth, they may still be a good addition to achieving a healthy biological age. These dietary supplements can be combined with studied natural ways to increase NAD+ such as proper diet and regular exercises like high-intensity interval training (HIIT).

There is still much to discover about the effectiveness of NAD+ boosting. The good thing is many human clinical trials are ongoing and available clinical experience supports its numerous potential benefits.

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional. We have assembled this article through in-depth research based on the information available at the date of publishing.  We may receive a small commission for purchases you make through our links, but this comes at no extra cost to you. This commission allows us to continue doing what we love through Health Plugged, which is delivering evidence-based health information to our readers worldwide.

Joanna is extremely passionate about empowering her readers to make informed health decisions. Her writing process involves intensive research and fact-checking, but she also enjoys writing health-related product-review articles that help readers make better choices. Her goal is to create highly-accessible and research-based content that readers can relate to and learn from. In her free time, Joanna loves reading self-help books.