Phosphatidylserine is a substance produced by the body but in small amounts. To manage its levels in the body, it is therefore recommended to eat foods containing it. Additionally, some of the best phosphatidylserine supplements have enough amounts to help increase the compound levels in the body.

If you’re looking for the best phosphatidylserine supplements to try, we’ve got a list of some of the best brands on the market! In this article, we’ll take a look at some of the best phosphatidylserine supplements you can buy.


Quick Summary

Best Value For Money: Double Wood Phosphatidylserine

Best Phosphatidylserine Powder: Bulk Supplements Phosphatidylserine

Most Premium Offer: Solgar Phosphatidylserine


BrandPhosphatidylserine Content Per ServingPrice/Number of Capsules/GramsDosage Recommendation
Double Wood Phosphatidylserine300 mg~$20/120
2 capsules daily
Lake Avenue Nutrition Sunflower Phosphatidylserine100 mg
  ~$29/1201 capsule daily with or without food
Jarrow Formulas PS 100100 mg~$33/1201 capsule up to three times daily with a meal


Bulk Supplements Phosphatidylserine100 mg
~$12/10 grams 
Take 500 mg or ⅕ teaspoon once or twice daily
Solgar Phosphatidylserine200 mg
~$47/601 softgel twice daily, preferably with a meal

Best Phosphatidylserine Supplements

Double Wood Phosphatidylserine

Double Wood Phosphatidylserine Review
PHOSPHATIDYLSERINE CONTENT PER SERVING:

300 mg

PRICE/NUMBER OF CAPSULES:

~$20/120

DOSAGE RECOMMENDATION:

2 capsules daily

Pros

  • Non-GMO
  • Gluten-free
  • GMP quality

Cons

  • Contains soy
  • Some side effects were reported

Double Wood is a trusted brand in the supplement world as it is known for producing high-quality products. Its phosphatidylserine is no exception as a third-party tested this supplement to ensure purity and quality. Additionally, it has a Certificate of Analysis as proof of complying with the highest standard. 

This supplement also aims to enhance the focus and attention of individuals by stabilizing stress levels and supporting glucose utilization. It also improves memory, especially in exhausted adults, and improves their speed and accuracy in recalling. Overall, the cognitive function of users can improve by taking this supplement.

Based on thousands of reviews on Amazon, this supplement is well-received by users. They noticed that their mental clarity improved as well as their memory. Also, some said that it helps with ADHD, while others experienced better sleep and focus as they continued to take the capsules. However, some reported side effects such as stomach upset. But overall, the consensus is positive.


Lake Avenue Nutrition Sunflower Phosphatidylserine

Lake Avenue Nutrition Sunflower Phosphatidylserine Review
PHOSPHATIDYLSERINE CONTENT PER SERVING:

100 mg

PRICE/NUMBER OF CAPSULES:

~$29/120

DOSAGE RECOMMENDATION:

1 capsule daily with or without food

Pros

  • Gluten-free
  • GMP quality
  • No soy
  • Non-GMO

Cons

  • Quite pricey

Lake Avenue Nutrition is also known for manufacturing supplements that are scientifically backed to ensure the quality and possible benefits of its products. Its phosphatidylserine supplement is also made from sunflower seeds and went through a 3-stage testing process to guarantee that it’s safe to consume. Moreover, the brand’s third-party testing laboratories are ISO accredited.

This supplement aims to aid in maintaining or improving the overall cognitive functions and brain health of its users. Moreover, feedback from verified users is positive as they claim to feel improvement in concentration and memory. Some also mentioned that it reduces their stress level.


Jarrow Formulas PS 100

Jarrow Formulas PS 100 Review
PHOSPHATIDYLSERINE CONTENT PER SERVING:

100 mg

PRICE/NUMBER OF CAPSULES:

~$33/120

DOSAGE RECOMMENDATION:

1 capsule up to three times daily with a meal

Pros

  • Gluten-free
  • No dairy, egg, fish, and shellfish
  • Free of peanuts and tree nuts

Cons

  • It’s expensive
  • Contains soy

The PS 100 for Jarrow Formulas contains the Cogni-PS formula which is a concentrated form of phosphatidylserine. You can also take 1 to 3 capsules per day as the brand suggests, as each capsule only contains 100 mg of the substance. It aims to maintain a healthy brain and promote attentiveness, reaction time, mental clarity, and overall cognitive functions.

Thousands of users took their time to also rate the product, and as it stands, it has a 4.6 rating in iHerb. The consensus is also positive, with many users saying it improved their memory and concentration. Additionally, some said that it helped control their mood swings as it puts them in a more relaxed state of mind. However, a few didn’t feel anything while others experienced side effects such as dizziness.


Bulk Supplements Phosphatidylserine

Bulk Supplements Phosphatidylserine Review
PHOSPHATIDYLSERINE CONTENT PER SERVING:

100 mg

PRICE/SIZE:

~$12/10 grams

DOSAGE RECOMMENDATION:

Take 500 mg or ⅕ teaspoon once or twice daily

Pros

  • Easy to consume
  • No additives and fillers
  • Free of artificial flavors

Cons

  • Contains soy

As one of the most trusted brands, this Bulk Supplements phosphatidylserine is also laboratory-tested to ensure quality and safety. Also, all of its products are tested in laboratories that follow the cGMP guidelines and standards. This supplement aims to support overall brain health and stimulate cognitive functions to improve memory, focus, and attentiveness.

In addition, it may also enhance athletic performance and aid in recovery after exercise if you have sore muscles. Since it’s in powder form, you can mix it with your chosen drink. Moreover, many users are happy about the benefits this supplement brings as they said it enhances their memory and improves recall clarity. However, some said the powder gets clumpy, so dissolving it may be a slight challenge.


Solgar Phosphatidylserine

Solgar Phosphatidylserine Review
PHOSPHATIDYLSERINE CONTENT PER SERVING:

200 mg

PRICE/NUMBER OF CAPSULES:

~$47/60

DOSAGE RECOMMENDATION:

1 softgel twice daily, preferably with a meal

Pros

  • No artificial flavors
  • Free of gluten, dairy, and wheat
  • Non-GMO

Cons

  • Contains soy
  • Very pricey

With over 70 years in the pocket, Solgar is also a standard in the industry in terms of quality and commitment to using responsibly sourced high-quality raw materials. Moreover, even their recyclable bottles are in excellent condition as it protects the capsules from heat and light to avoid creating moisture inside. The brand also adheres to its high standards, such as integrating USP water filtration and HEPA air filtration into the manufacturing process.

Its premium phosphatidylserine supplement aims to improve or maintain overall brain health, especially for those experiencing a decline in cognitive functions as they age. Moreover, user feedback consensus is primarily positive as many experienced a boost in their memory and focus. Furthermore, some said their sleep patterns also improved.


How to Choose the Best Phosphatidylserine Supplement

There are a few factors to keep in mind when looking out for the top phosphatidylserine supplement. They include the following:-

  • Third-party lab-testing: Third-party lab testing is typically conducted to ensure the quality and purity of the products you receive. These tests usually check for the accuracy of the ingredient label, ensuring that the quantity of the active ingredient meets what’s stated on the label. Additionally, these tests also ensure the product is free from harmful levels of contaminants such as heavy metals.
  • Formulation: If you enjoy mixing your supplement with a drink, a powder form may be more suitable. Those who hate swallowing capsules will likely also prefer a powder supplement.
  • Brand reputation: Buying from a reputable and established brand ensures you get quality products. Look out for brands that have a long-standing record and large customer base because this is probably a good indicator of their product quality and standards.
  • Dose per capsule: If you want to consume fewer tablets daily, look out for a supplement with a higher dose per capsule. On our list, Solgar leads the pack with 200mg of phosphatidylserine per capsule.

What Are The Benefits of Phosphatidylserine Supplements?

Consuming it may also result in many health benefits that help many people with different medical conditions. It’s considered an essential substance as it also aids in the multiple functions of the body. Moreover, it’s a component that plays a crucial role in keeping your nerve cell membranes healthy, which helps you keep a sharp memory. [1]

If exercising is in your routine, a published report concluded that your endurance and even your athletic performance might improve due to phosphatidylserine supplements. [2] Also, those who have depression might be able to regulate their mood with the help of this substance.

According to the study, patients diagnosed with severe depression took it along with omega-3 fatty acids. Based on their depression scores, the trial also concluded that it improved their situation. [3]

Moreover, those who experience memory loss as they age can also benefit from the best phosphatidylserine supplements. A study showed that those with declining cognitive functions improved their memory significantly due to taking phosphatidylserine. [4] Other benefits may also include aiding those with ADHD, anxiety, Alzheimer’s disease, and multiple sclerosis.

Frequently Asked Questions:

What Are The Side Effects Of Phosphatidylserine?

Taking phosphatidylserine may have possible side effects such as stomach pains and insomnia. [1] However, for the elderly, consuming a dose of up to 600 mg for up to 12 weeks did not result in any harm. [5]

Furthermore, for those taking other medications, be aware of the possibility of phosphatidylserine having a blood-thinning effect. Also, there are not enough studies that include pregnant and nursing women, so it’s best to consult a doctor before taking any phosphatidylserine supplement.

Does Phosphatidylserine Cause Cancer?

There seems to be no evidence that suggests phosphatidylserine can cause cancer. There are, however, some studies that aim to find out if it can help suppress tumors.

How Much Phosphatidylserine Should I Take?

According to research, taking 100 mg up to three times daily can also help improve memory. In general, 300 mg to 800 mg can be consumed safely and efficiently. [1]

Which Is Better Phosphatidylcholine Or Phosphatidylserine?

They are both integral components of the cell membrane, but one of their major differences is their location in the cell membrane structure. [6] Based on their functions, phosphatidylcholine may be a better option since it can also supply phosphatidylserine. [7]

Does Phosphatidylserine Help With Sleep?

Based on user feedback, yes, it does. The best phosphatidylserine supplements may assist in mood regulation, as mentioned, resulting in reduced stress and therefore better-sleeping patterns.

Bottomline: Best Phosphatidylserine Supplements

Despite being a natural substance produced by the body, consuming food and supplements containing phosphatidylserine is needed to maintain healthy levels. This article provides a list of the best phosphatidylserine supplements and the most important information about each one. Moreover, user feedback is also provided as additional knowledge to guide you with your choice.

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional. We have assembled this article through in-depth research based on the information available at the date of publishing.  We may receive a small commission for purchases you make through our links, but this comes at NO extra cost to you. This commission allows us to continue doing what we love through Health Plugged, which is delivering evidence-based health information to our readers worldwide.

Editorial References And Fact-Checking

  • Glade, M. J., & Smith, K. (2015). Phosphatidylserine and the human brain. Nutrition, 31(6), 781–786. https://doi.org/10.1016/j.nut.2014.10.014
  • Kingsley M. (2006). Effects of phosphatidylserine supplementation on exercising humans. Sports medicine (Auckland, N.Z.)36(8), 657–669. https://doi.org/10.2165/00007256-200636080-00003
  • Komori T. (2015). The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression. Mental illness7(1), 5647. https://doi.org/10.4081/mi.2015.5647
  • Kato-Kataoka, A., Sakai, M., Ebina, R., Nonaka, C., Asano, T., & Miyamori, T. (2010). Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints. Journal of Clinical Biochemistry and Nutrition, 47(3), 246–255. https://doi.org/10.3164/jcbn.10-62
  • Jorissen, B. L., Brouns, F., Van Boxtel, M. P., & Riedel, W. J. (2002). Safety of soy-derived phosphatidylserine in elderly people. Nutritional neuroscience5(5), 337–343. https://doi.org/10.1080/1028415021000033802

Beatriz is an exceptional freelance medical writer. This is a craft she has been honing since her university years. Beatriz also has experience writing content in the health and wellness field, which she is extremely passionate about. She aims to help her readers understand their health and wellness deeper and make better health-related decisions. LinkedIn