Tauroursodeoxycholic acid, a.k.a TUDCA, is fast becoming a popular ingredient in the best supplements for its numerous health benefits. Moreover, TUDCA is a bile acid that occurs, in small amounts, naturally in the body. It’s released from the gallbladder to help the body better digest fats.

Are you looking for the best TUDCA supplements to try? Well, we’ve got a list of some of the best brands on the market! In this article, we’ll take a look at some of the top TUDCA supplements you can buy.


Quick Summary

Most Added Value: KoNefancy Advanced TUDCA

Highest Rated: Nutricost TUDCA

Most Expensive: BodyBio TUDCA

Highest TUDCA Content With Value For Money: Double Wood Supplements TUDCA


BrandTUDCA Content per ServingPrice/Number of CapsulesDosage Recommendation
Double Wood Supplements TUDCA500 mg~$28/602 capsules daily on an empty stomach
BodyBio TUDCA500 mg
~$55/602 capsules daily with food
Nutricost TUDCA250 mg~$30/601 capsule daily 8-12 oz water

HUMANX TUDCA1000 mg
~$35/60
2 capsules daily with water
KoNefancy Advanced TUDCA800 mg
~$27/602 capsules daily with a meal

Best TUDCA Supplements

Double Wood Supplements TUDCA

Double Wood Supplements TUDCA
TUDCA CONTENT PER SERVING:

500 mg

PRICE/NUMBER OF CAPSULES:

~$28/60

DOSAGE RECOMMENDATION:

2 capsules daily on an empty stomach

Pros

  • Non-GMO and gluten-free
  • Third-party tested to assure quality
  • Money-back guarantee
  • Affordable

Cons

  • Some side effects reported by a few users

This TUDCA supplement manufactured by Double Wood also went through third-party testing to ensure quality and potency. A Certificate of Analysis is also on the brand website to prove compliance with industry standards.  It promotes the maintenance of liver health as well as eye health. As per the brand, do not consume TUDCA before drinking alcohol as it can negatively impact your liver.

Based on thousands of reviews, the consensus is positive with some negatives due to side effects experienced. Users also noted that it caused nausea, headaches, and swelling. They also reported an unpleasant smell that comes from the capsules. 

However, despite all that, there are many more who are happy with the results and benefits. Several users who had severe illnesses noted that this supplement gave them the energy boost they needed, while others remarked that the supplement seemed to help with ‘cleaning up’ their bile ducts.


BodyBio TUDCA

BodyBio TUDCA
TUDCA CONTENT PER SERVING:

500 mg

PRICE/NUMBER OF CAPSULES:

~$55/60

DOSAGE RECOMMENDATION:

2 capsules daily with food

Pros

  • No fillers or additives
  • No artificial colors
  • Free of soy, wheat, gluten, and dairy
  • Undergoes extensive testing before encapsulation

Cons

  • Expensive
  • Includes gelatin

Made by a trusted brand, this TUDCA supplement also went through extensive research and testing to provide the best benefits to users. Additionally, the brand conducts Internal and external checks and tests to ensure the quality of the product. This supplement aims to support inflammation response, stabilize the cell membrane, assist in clearing toxins, aid in treating liver diseases, regulate the immune system, and so much more.

User feedback is positive overall, with many happy with how easy to swallow the capsules are. Moreover, many users have said that it helped improve their liver health and remove their gallbladder pain. However, a few users experienced nausea and cramping as side effects.

The BodyBio brand has been operating for over 25-years and counting as a family-owned and run business, which is why it is highly trusted by physicians and customers alike.


Nutricost TUDCA

Nutricost TUDCA
TUDCA CONTENT PER SERVING:

250 mg

PRICE/NUMBER OF CAPSULES:

~$30/60

DOSAGE RECOMMENDATION:

1 capsule daily 8-12 oz water

Pros

  • Gluten-free
  • Free of soy
  • Non-GMO

Cons

  • Quite pricey
  • Unpleasant taste
  • Some side effects 

Nutricost uses synthetic TUDCA instead of sourcing from bear bile as it is considered inhumane. Then, the supplement goes through testing conducted by ISO-accredited third-party labs to ensure each capsule’s quality, potency, and safety. Moreover, its benefits include emulsifying fats in the intestines to aid with absorption. Furthermore, it supports liver health and the overall functions of the body.

Some users experienced nausea and cramping as side effects, but the consensus is positive overall. According to users, it also helped decrease their liver ALT, liver enzymes, and gallbladder inflammation based on their blood test results. Additionally, many of them felt less bloated and were happy with the supplement’s detoxifying impact.


HUMANX TUDCA

HUMANX
TUDCA CONTENT PER SERVING:

1000 mg

PRICE/NUMBER OF CAPSULES:

~$35/60

DOSAGE RECOMMENDATION:

2 capsules daily with water

Pros

  • No artificial flavor
  • Vegetarian and vegan-friendly
  • No binders
  • No major food allergens 

Cons

  • A bit expensive

This supplement is also made from a proprietary blend of milk thistle extract, TUDCA, and pterostilbene. The additional ingredients also provide more antioxidants which have numerous health benefits as well. Moreover, HumanX TUDCA aims to promote liver health and aid in treating liver-related diseases. Additionally, the product is made in a GMP-certified facility to ensure that the process of manufacturing it is up to industry standards. It is also third-party tested to ensure quality and potency.

Overall, the reviews are great and positive, with many users happy with the supplement’s effectiveness. Aside from maintaining liver health, some also said it improves their cognitive functions and gives them an energy boost. It also helped with reducing inflammation and better focus throughout the day. Although, some users are not happy that the formulation includes other ingredients, not just TUDCA.


KoNefancy Advanced TUDCA

KoNefancy Advanced
TUDCA CONTENT PER SERVING:

800 mg

PRICE/NUMBER OF CAPSULES:

~$27/60

DOSAGE RECOMMENDATION:

2 capsules daily with a meal

Pros

  • Added nutrients
  • Non-GMO
  • Free of wheat, soy, gluten, and dairy

Cons

  • A bit expensive

This supplement is safe for vegans and was manufactured following the strictest quality controls with Good Manufacturing Process (GMP). It also has numerous other ingredients such as Humic and Fulvic acids, which help improve minerals in the body and support the immune system. Additionally, it contains an herbal blend that includes beetroot, milk thistle extract, chanca piedra extract, artichoke extract, chicory, and dandelion extract. Furthermore, all of this helps enhance the health benefits of this product.

A lot of users are also happy with its impact as they said it helped them improve their digestion, maintain liver health, remove pain, and boost their energy. Furthermore, some used it to lose weight and felt good about the detox effect of the supplement. They also liked how easy to swallow the capsules are.


How to Choose the Best TUDCA Supplements

Brand reputation and transparency are key. Ensure you purchase these supplements from a brand with an established positive track record of reviews and customer satisfaction. This can be done by looking at previous client reviews. Third-party testing also helps assure the quality and safety of the products.

It’s also best to go for supplements with no artificial flavorings, fillers, or coloring.

What Are The Benefits of TUDCA Supplements?

Chinese medicine has used TUDCA for a long time, and its current traction stems from its impact on bodily functions, from the brain to the liver, kidneys, and other organs [1].

One of its benefits is also aiding in the treatment of liver cirrhosis, where healthy cells are replaced by scar tissues. Moreover, based on a study involving 18 patients, the consumption of TUDCA was effective in the treatment of liver cirrhosis. [2

Another big possible health benefit is the treatment of cholestasis which is the condition wherein there is an accumulation of bile in the liver and a lack of it in the small intestines. [3] Moreover, TUDCA reduced cholestasis caused by liver injury caused by poor blood flow to the liver. [4]

Moreover, there are other health benefits from TUDCA supplements are Hepatitis, ALS, Alzheimer’s, and Parkinson’s. However, more research needs to be conducted to get conclusive evidence on how TUDCA can treat the said illnesses.

Frequently Asked Questions:

What does TUDCA do for the liver?

TUDCA is used to improve the overall health of the liver. One study shows that 12 women with PBC consumed TUDCA for 2 months and also decreased their liver enzymes by 51%. [5] Additionally, the best TUDCA supplements help detoxify the liver of toxins or aid in treating liver-related illnesses.

Does TUDCA have side effects?

Generally, TUDCA supplements are safe to consume as long as users follow the dosage recommendation of either the brand or healthcare professional. However, diarrhea was noted as a side effect of consuming a dosage of 1,000 – 1,500 mg of TUDCA. [6]

Moreover, since there is still limited research on how it impacts pregnant and nursing women, it is better to consult a doctor first before taking any TUDCA supplement.

Is TUDCA a ursodiol?

It is also a taurine conjugated form of ursodeoxycholic acid (UDCA) with greater hydrophilicity. [7]

Is TUDCA anti-inflammatory?

Based on studies, it can also reduce gut inflammation. [8] Many users who used the aforementioned best TUDCA supplements said their gallbladder inflammation was reduced due to taking the capsules.

Bottomline: Best TUDCA Supplements

TUDCA is a substance produced by the body naturally but in small amounts only. Thus, manufacturers also use it in supplement form and offer higher doses to maximize the health benefits. Many supplements are also available in the market, which is why this article has compiled the best TUDCA supplements to help you make the right choice.

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional. We have assembled this article through in-depth research based on the information available at the date of publishing.  We may receive a small commission for purchases you make through our links, but this comes at no extra cost to you. This commission allows us to continue doing what we love through Health Plugged, which is delivering evidence-based health information to our readers worldwide.

Editorial References And Fact-Checking

  • Nunes, A. F., Amaral, J. D., Lo, A. C., Fonseca, M. B., Viana, R. J., Callaerts-Vegh, Z., D’Hooge, R., & Rodrigues, C. M. (2012). TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. Molecular neurobiology45(3), 440–454. https://doi.org/10.1007/s12035-012-8256-y
  • Pan, X. L., Zhao, L., Li, L., Li, A. H., Ye, J., Yang, L., Xu, K. S., & Hou, X. H. (2013). Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban33(2), 189–194. https://doi.org/10.1007/s11596-013-1095-x
  • Hofmann A. F. (2002). Cholestatic liver disease: pathophysiology and therapeutic options. Liver22 Suppl 2, 14–19. https://doi.org/10.1034/j.1600-0676.2002.00002.x
  • Baiocchi, L., Tisone, G., Russo, M. A., Longhi, C., Palmieri, G., Volpe, A., Almerighi, C., Telesca, C., Carbone, M., Toti, L., De Leonardis, F., & Angelico, M. (2008). TUDCA prevents cholestasis and canalicular damage induced by ischemia-reperfusion injury in the rat, modulating PKCalpha-ezrin pathway. Transplant international : official journal of the European Society for Organ Transplantation21(8), 792–800. https://doi.org/10.1111/j.1432-2277.2008.00682.x
  • Invernizzi, P., Setchell, K. D., Crosignani, A., Battezzati, P. M., Larghi, A., O’Connell, N. C., & Podda, M. (1999). Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. Hepatology (Baltimore, Md.)29(2), 320–327. https://doi.org/10.1002/hep.510290220
  • Crosignani, A., Battezzati, P. M., Setchell, K. D., Invernizzi, P., Covini, G., Zuin, M., & Podda, M. (1996). Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study. Digestive diseases and sciences41(4), 809–815. https://doi.org/10.1007/BF02213140
  • Ma, H., Zeng, M., Han, Y., Yan, H., Tang, H., Sheng, J., Hu, H., Cheng, L., Xie, Q., Zhu, Y., Chen, G., Gao, Z., Xie, W., Wang, J., Wu, S., Wang, G., Miao, X., Fu, X., Duan, L., Xu, J., … Jia, J. (2016). A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Medicine95(47), e5391. https://doi.org/10.1097/MD.0000000000005391

Beatriz is an exceptional freelance medical writer. This is a craft she has been honing since her university years. Beatriz also has experience writing content in the health and wellness field, which she is extremely passionate about. She aims to help her readers understand their health and wellness deeper and make better health-related decisions. LinkedIn