Finding it difficult to get a good night’s sleep is a problem that affects many people; it is not an isolated problem. Many people struggle with sleep-related issues and seek different treatments to enhance their sleep.
This article compares the effects of CBD Vs. Melatonin For Sleep, highlighting their differences, advantages, and possible drawbacks. CBD and melatonin have both drawn a lot of interest as sleep aids.
Table of Contents
What Are CBD And Melatonin?

What Are CBD and Melatonin? Explore the intriguing world of these two natural compounds and their potential benefits for sleep and well-being.
Cannabidiol (CBD)
Cannabidiol, or CBD, is a chemical from the Cannabis sativa plant. In contrast to THC (tetrahydrocannabinol), CBD is not psychoactive and does not cause a “high.” It has grown in popularity because of its conceivable health advantages, such as pain relief and anxiety reduction. [1]
Melatonin
In response to darkness, the pineal gland naturally produces the hormone melatonin. In synthetic form, it is frequently used as an over-the-counter sleep aid and aids in regulating the sleep-wake cycle. [2]
Both CBD and melatonin are offered in several formats, including tinctures, gummies, and pills. CBD can also be vaped, while Melatonin is sometimes used as a topical application or a liquid.
CBD is generally legal in many parts of the world, but its legal status can vary by country and state. Melatonin is usually available over the counter and is widely considered safe when used appropriately.
CBD interacts with the body’s endocannabinoid system, affecting various physiological processes, including sleep. Melatonin, on the other hand, works by mimicking the effects of the natural hormone to promote sleepiness.
CBD Vs. Melatonin For Sleep

Both supplements are widely recognized as sleep aids, but they function differently in our bodies and offer unique benefits and potential drawbacks.
This section will delve into the core contrasts between CBD and Melatonin, laying out the differences in their effectiveness, onset, and other features.
CBD vs. Melatonin: Differences
- Onset of Action: Melatonin typically works faster, often within 30 minutes to an hour, making it ideal for those who need quick relief. [3] In contrast, the sleep-inducing effects of CBD may take longer to manifest.
- Duration of Effect: CBD usually has a longer-lasting impact, potentially relieving insomnia. [4] Melatonin is often effective in helping people fall asleep but doesn’t always help them stay asleep.
- Mechanism of Action: While CBD interacts with the endocannabinoid system to affect various physiological processes, including sleep, Melatonin focuses solely on the sleep-wake cycle by mimicking a hormone naturally produced by the body.
- Side Effects: Melatonin generally has fewer side effects and interacts less with other medications. However, CBD can cause dry mouth, lower blood pressure, and interact with other drugs.
- Variability of Effects: The effectiveness of CBD can be more variable from person to person due to differences in how individuals process it, whereas Melatonin usually has more predictable results.
Understanding these CBD vs. melatonin differences can help you select the sleep aid that is most appropriate for your needs.
CBD Vs. Melatonin Side Effects

When opting for natural sleep aids like CBD or Melatonin, weighing their potential benefits against the risks is vital. While both are generally considered safe for many individuals, they come with their own side effects.
Here are the most cited CBD Vs. Melatonin Side Effects:
CBD vs. Melatonin: Risks

CBD:
- Dry Mouth: A common side effect, dry mouth can cause discomfort and frequent thirst.
- Low Blood Pressure: High doses can temporarily drop blood pressure, posing risks for those with heart conditions.
- Drowsiness: While helpful for sleep, excessive drowsiness can be a concern, especially during daytime activities.
- Liver Issues: Prolonged use, particularly in high doses, can put added stress on the liver.
- Drug Interactions: CBD can affect how other drugs are metabolized, potentially changing their effectiveness or causing adverse effects. [5]
Melatonin:
- Dizziness: Some users experience a light-headed feeling, which can be unsettling.
- Headaches: These can range from mild to severe and often dissipate after discontinuing use.
- Nausea: Some consumers may experience stomach discomfort or even vomiting.
- Daytime Sleepiness: High doses may cause drowsiness the next day, affecting performance in daily activities.
- Dependence: Though it’s uncommon, psychological dependence is possible and could make it difficult to fall asleep without melatonin. [6]
CBD vs. Melatonin: Which Is Better?

The best choice may differ from person to person, depending on their medical history and particular needs. How their body reacts to each supplement, so there is no universally applicable answer to this question.
For those who want to fall asleep more quickly, melatonin may be the best choice. For short-term use, it is typically regarded as secure and efficient. On the other hand, those who need a longer-lasting effect or experience other symptoms like pain or anxiety may benefit more from CBD.
Particularly if you’re pregnant, nursing, or taking any other medications, you should only use these supplements under the guidance of a doctor. A doctor can provide individualized advice and may recommend specific tests or dosages.
Eventually, some might discover that a CBD and melatonin mix works best for them. However, caution and medical supervision are advised due to the scant research on using CBD and melatonin together.
Conclusion
When it comes to enhancing the quality of sleep, both CBD and melatonin have specific advantages and disadvantages. When choosing between CBD and melatonin for sleep, you should consider your needs, potential side effects, and other health factors.
Always seek medical advice if you want the best information that is personalized for you. It is impossible to overstate the importance of getting a good night’s sleep; CBD and melatonin offer ways to achieve it.
FAQs
Disclaimer: This article is only a guide. It does not substitute the advice given by your healthcare professional. Before making any health-related decision, consult your healthcare professional.
Editorial References And Fact-Checking
- Rapin, L., Gamaoun, R., El Hage, C., Arboleda, M. F., & Prosk, E. (2021). Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic. Journal of cannabis research, 3(1), 1-10.
- Carpentieri, A., De Barboza, G. D., Areco, V., López, M. P., & De Talamoni, N. T. (2012). New perspectives in melatonin uses. Pharmacological research, 65(4), 437-444.
- Costello, R. B., Lentino, C. V., Boyd, C. C., O’Connell, M. L., Crawford, C. C., Sprengel, M. L., & Deuster, P. A. (2014). The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutrition journal, 13, 1-17.
- Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in anxiety and sleep: a large case series. The Permanente Journal, 23.
- Kaul, M., Zee, P. C., & Sahni, A. S. (2021). Effects of cannabinoids on sleep and their therapeutic potential for sleep disorders. Neurotherapeutics, 18, 217-227.
- Tuft, C., Matar, E., Menczel Schrire, Z., Grunstein, R. R., Yee, B. J., & Hoyos, C. M. (2023). Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Clinical Interventions in Aging, 49-59.