How does Cissus quadrangularis affect testosterone? Read on to find out!

The Cissus quadrangularis plant is a perennial member of the grape family. It is also known as adamant creeper, winged treebine, and veldt grape. The species was once found in the tropical regions of Africa, the Arabian Peninsula, and tropical Asia.

There are plenty of healthy nutrients, like vitamin C, antioxidants, calcium, and phosphorus, in this plant. This plant’s stem extracts have been used for generations in India to treat gout, back pain, and fractures.

Cissus quadrangularis has been traditionally used to treat various conditions, including diabetes, obesity, high cholesterol, bone fractures, allergies, cancer, stomach upset, painful menstrual periods, asthma, malaria, wound healing, peptic ulcer disease, weak bones, osteoporosis, and peptic ulcer disease.

However, this article will look at the science behind Cissus quadrangularis and its effects on testosterone levels. Now let’s explore how Cissus quadrangularis affects this hormone.

What are the Effects of Cissus quadrangularis on Testosterone?

One of testosterone’s many vital roles in both sexes makes it an essential chemical in the human body. However, it is created naturally in men to a far lower degree in women.

Free Testosterone is the active form of testosterone that promotes muscle development and protein synthesis at the cellular level. Long-term low testosterone levels may weaken bones, increasing the risk of fractures.

According to a few studies, Cissus quadrangularis has been shown to alleviate joint discomfort and speed recovery time of bone fracture or after exercise. The Cissus quadrangularis plant is said to possess bone-repair properties due to the presence of 3-ketosteroids. [1]

The use of Cissus quadrangularis has been linked to increased testosterone levels and decreased cortisol levels. Consequently, it may help athletes and bodybuilders gain muscle and strength.

Also, due to the ability of Cissus quadrangularis to act as a glucocorticoid antagonist, it has been proposed to possess anabolic/ androgenic activity. However, no studies have demonstrated that Cissus quadrangularis increased testosterone.

Anecdotally, Cissus quadrangularis may help to increase testosterone levels and reduce body fat, two factors that can improve sports performance and bodybuilding results.

Cissus quadrangularis Side Effects

Cissus quadrangularis is safe to try. However, more studies are needed to prove its health benefits and learn more about its side effects and long-term effects.

If taken as directed (up to 10 weeks), Cissus quadrangularis may not cause any adverse effects. Most people have no problems with it. Possible adverse reactions include pain in the head, stomach, and bowels, fatigue, and difficulty sleeping.

Furthermore, Cissus quadrangularis may cause hypoglycemia and may impede blood sugar regulation before, during, and after surgery. Cissus quadrangularis should be avoided for two weeks before surgery.

Cissus quadrangularis Dosage

There is no established standard dose for Cissus quadrangularis. Most supplements may be found in powder, pill, or syrup form, and they can be purchased from various sources, including natural health stores, drug stores, and online. Most of these medicines are meant to be taken once daily, in dosages of 500 to 1,000 mg.

The suggested daily dose of Cissus for joint pain relief is 300mg extract standardized to 2.5% ketosteroids. In humans, this concentration has a measurable biological effect.

On the other hand, research has shown that dosages between 300 and 3,200 mg daily are effective. It would be ideal if you began with a smaller dose and gradually increased it to check your tolerance. Like any other dietary supplement, Cissus quadrangularis should be used only after discussing its use with a trusted medical professional.

How Long Should You Take Cissus quadrangularis?

Animal and cell research suggests that C. quadrangularis may stimulate the production of new bone cells and the mineralization of existing ones. It is also possible that it will prevent the gene production of cytokines, which are factors that lead to bone loss. [2, 3]

How Long Does Cissus quadrangularis Take to Work?

Cissus can alleviate inflammation and soreness in joints within 30 minutes after consumption. If you have persistent joint pain, using cissus regularly will help alleviate your symptoms over time. Numerous studies have shown that taking 300mg of Cissus daily for 8-30 weeks has no negative side effects for healthy adults (even athletes). Cissus should be used daily for a minimum of six to ten weeks for the best results.

Bottom line: Effects of Cissus Quadrangularis on Testosterone

Though more research is needed, Cissus quadrangularis could be a promising supplement for those with low testosterone levels struggling with bone health. This plant has been shown to positively affect testosterone levels, bone health, and joint recovery time – all important factors in overall fitness and well-being.

Its anti-inflammatory and pain-relieving effects may help athletes recover from exercise or injury. If you’re looking for a natural w your testosterone levels, Cissus quadrangularis may be worth considering. However, always consult with your doctor before taking any supplements, especially if you have a medical condition.

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional.

Editorial References and Fact Checking

  • Brahmkshatriya HR, Shah KA, Ananthkumar GB, Brahmkshatriya MH. Clinical evaluation of Cissus quadrangularis as osteogenic agent in maxillofacial fracture: A pilot study. Ayu. 2015 Apr-Jun;36(2):169-73. doi: 10.4103/0974-8520.175542. PMID: 27011718; PMCID: PMC4784127.
  • Muthusami S, Ramachandran I, Krishnamoorthy S, Govindan R, Narasimhan S. Cissus quadrangularis augments IGF system components in human osteoblast like SaOS-2 cells. Growth Horm IGF Res. 2011 Dec;21(6):343-8. doi: 10.1016/j.ghir.2011.09.002. Epub 2011 Oct 19. PMID: 22015109.
  • Tasadduq R, Gordon J, Al-Ghanim KA, Lian JB, Van Wijnen AJ, Stein JL, Stein GS, Shakoori AR. Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre-Osteoblastic MC3T3-E1 Cells. J Cell Physiol. 2017 Mar;232(3):540-547. doi: 10.1002/jcp.25449. Epub 2016 Jun 15. PMID: 27264191; PMCID: PMC5115982.


  • Shaira Urbano, Licensed Pharmacist

    Shaira is a licensed pharmacist (Bachelor of Pharmacy) and an experienced content writer. She enjoys inspiring and informing her readers through research-backed, comprehensive health content. Shaira draws from her personal experience working with real-life patients in a hospital setting and is currently pursuing her passion in writing.


Shaira is a licensed pharmacist (Bachelor of Pharmacy) and an experienced content writer. She enjoys inspiring and informing her readers through research-backed, comprehensive health content. Shaira draws from her personal experience working with real-life patients in a hospital setting and is currently pursuing her passion in writing.