Pregnenolone is a natural steroid hormone produced in the body by the adrenal glands and can also be taken as a supplement. It has been studied for its potential anti-inflammatory, cognitive-enhancing, antidiabetic, and antiaging effects. Pregnenolone has a broad range of chemical effects on the brain and may have a role in various psychiatric disorders.

This article will overview pregnenolone, including its potential benefits, side effects, and recommended supplement dosages. Now, let’s start.

What is Pregnenolone Supplement Used For?

Pregnenolone is known to help boost energy, improve cognitive functioning, and reduce stress. Studies suggest that Pregnenolone may help with anxiety, depression, fatigue, memory loss, and other mental health issues.

What is Pregnenolone Supplement Made From?

The steroid precursor pregnenolone (starter material) I s a byproduct of cholesterol synthesis in the body. Pregnenolone production requires several substances, including cholesterol, vitamin A, thyroid hormone, and enzymes. Any of these deficits will result in a less-than-ideal level of pregnenolone in your system.

Pregnenolone is made from natural sources such as wild yam, soy, or corn. It can be taken in capsule form, as a pill, or injected.

What Does Pregnenolone Do For You?

Let’s look into its potential benefits in detail. Pregnenolone has a range of potential benefits, including the following.

1. Pregnenolone Male Benefits

Testosterone is essential to the health of males on a wide variety of fronts. Low testosterone levels can have far-reaching consequences for a man’s mental and physical health, his ability to grow muscle, and his libidinal and sexual motivation.

While there are situations where therapeutic testosterone injections are required, it’s possible that supplementation can help the body create adequate amounts of the hormone on its own.

In males, Pregnenolone is known to boost testosterone levels and increase libido and sexual performance. Supplementing with pregnenolone guarantees that the body has what it needs to generate other vital hormones, including testosterone, as long as there is no physical reason why the body cannot make enough testosterone on its own.

Pregnenolone is also known to help with cognitive functions in men by improving memory recall, focus, and concentration. It may help treat male infertility issues as well.

2. Pregnenolone for Memory Health

According to a preliminary study, pregnenolone shows promise in protecting against memory loss that comes with age. Brain Research Reviews released an article in 2001 that summarized the research on the impact of steroid hormones on cognition in the elderly. [1]

Because it promotes new brain cell formation, pregnenolone has been shown to have a remarkable impact on mental acuity. It promotes the development of new synapses and has neuroprotective effects by increasing the creation of myelin, a fatty coating that insulates neurons and improves their function.

However, studies also state that human-based studies on pregnancy and memory have generated inconsistent findings, despite evidence from animal research suggesting that pregnancy may improve memory.

3. Pregnenolone for Schizophrenia

Schizophrenia is only one of several neuropsychiatric illnesses that have been researched for their potential to benefit from pregnenolone’s therapeutic effects. According to a study, patients with chronic schizophrenia or schizoaffective disorder who were administered pregnenolone (30 mg/day) for eight weeks showed considerable improvements in their symptoms. [2]

4. Pregnenolone for Sleep

Pregnenolone helps improve the quality of sleep and reduce insomnia-related symptoms. However, it should not replace regular sleeping habits such as going to bed simultaneously each night, avoiding caffeine and other stimulants, and limiting stress.

Pregnenolone supplements, according to human research, extend a person’s time spent in deep sleep (slow-wave sleep). Both pregnenolone and allopregnanolone, from which it is derived, have been demonstrated in studies to promote restorative sleep, making them helpful in treating insomnia and other sleep disorders.

As a result, this can have a multiplicative effect on pregnenolone’s other advantages, improving mood, reducing anxiety, and enhancing memory.

5. Pregnenolone for Weight Loss

One of the many reasons that pregnenolone is such an efficient stress reliever is that it suppresses the synthesis of the hormone cortisol. Considering that cortisol causes belly fat, this is a helpful strategy for slimming down.

Pregnenolone, similarly, has the effect of naturally increasing testosterone levels, which can increase metabolism and lead to weight loss by decreasing cortisol levels. [3]

6. Pregnenolone for Menopause

Pregnenolone has not been found to produce any significant effects on hormone levels and should not be used as a supplement. It may help improve mood by reducing stress and anxiety, but it should not replace estrogen or other hormones needed during menopause.

7. Pregnenolone for Depression

Pregnenolone has been shown to have positive effects on mood and cognition. It has therapeutic potential as an all-natural anti-depressant.

People with a bipolar illness or manic depression may benefit from pregnenolone for their depression. Patients who took the prohormone as an adjunct treatment for depression for 12 weeks had a higher rate of full recovery. [4]

Another research looked at the effects of pregnenolone on cognition and mood in individuals with bipolar disorder or recurrent major depressive disorder who also had a history of drug addiction. This supports the hypothesis that prohormone may be linked to reduced levels of mania and depression. Despite this, the study’s findings showed no significant cognitive improvements. [5]

What Dose of Pregnenolone Should I Take?

Pregnenolone dosage considerations include patient age, general health, and other characteristics. Unfortunately, the data needed to establish a safe dosage range for pregnenolone is currently lacking.

Pregnenolone dosing advice is currently unavailable due to insufficient scientific data. Because of the preliminary nature of the available data, it is premature to prescribe this medicine to treat any ailment. Make sure to seek advice from your doctor, pharmacist, or other healthcare experts before using any new medication.

Self-treatment of an illness or injury and subsequent refusal or postponement of appropriate medical attention can have major consequences. Always check with your doctor before using it for yourself or a family member.

Keep in mind that the safety of supplements has yet to be established and that dietary supplements are often unregulated. There is a possibility that the product will provide dosages that vary from the amounts advertised for each plant. Other contaminants, such as metals, may contaminate the product in other circumstances.

Furthermore, it has not been determined whether or if supplements are safe for pregnant and nursing mothers, young children, or those with preexisting medical issues or who are on medications.

Side Effects of Pregnenolone

Pregnenolone, when taken orally, may be safe for most persons for up to 12 weeks. It may also produce side effects such as skin rashes, acne, hair loss, diarrhea, constipation, trouble sleeping, restlessness, anxiety, sweating, or tremor in some users. Also, possible side effects include heart palpitations, depression, hunger changes, and muscular soreness.

The side effects of pregnenolone include stomach pain, nausea, vomiting, and headache. It may also increase the frequency of headaches. An irregular heartbeat is another possible side effect of taking too many supplements.

Pregnenolone can also cause insomnia if taken in large doses or long-term dosages. Anxiety and panic episodes have been linked to taking more than the prescribed dose. In excess, pregnenolone may prevent sleep rather than facilitate it.

Like just about anything else, it can have some unintended consequences. Talking to your doctor before taking it as a supplement or medication is important.

Bottom Line: Pregnenolone Benefits, Side Effects, and Dosages

Pregnenolone is a hormone with many potential benefits that occur naturally in the body. It can be taken as a supplement to help with conditions like cognitive decline, anxiety, depression, and fatigue.

Pregnenolone is generally considered safe, but as with any supplement, it’s always best to talk to your doctor before starting anything new.

Disclaimer: This article is only a guide. It does not substitute the advice given by your own healthcare professional. Before making any health-related decision, consult your healthcare professional.

Editorial References and Fact Checking

  • Yvette Akwa, PhD. Pregnenolone Sulfate an Early Marker of the Memory Loss in Alzheimer’s Disease (STERMEM). Assistance Publique – Hôpitaux de Paris. June 3, 2009. NCT00912886. P071237.
  • Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep 15;191:78-90. doi: 10.1016/j.neuroscience.2011.06.076. Epub 2011 Jul 1. PMID: 21756978.
  • Pintor C, Loche S, Faedda A, Fanni V, Nurchi AM, Corda R. Adrenal androgens in obese boys before and after weight loss. Horm Metab Res. 1984 Oct;16(10):544-8. doi: 10.1055/s-2007-1014845. PMID: 6238894.
  • Brown ES, Park J, Marx CE, Hynan LS, Gardner C, Davila D, Nakamura A, Sunderajan P, Lo A, Holmes T. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology. 2014 Nov;39(12):2867-73. doi: 10.1038/npp.2014.138. Epub 2014 Jun 11. PMID: 24917198; PMCID: PMC4200497.
  • Osuji IJ, Vera-Bolaños E, Carmody TJ, Brown ES. Pregnenolone for cognition and mood in dual diagnosis patients. Psychiatry Res. 2010 Jul 30;178(2):309-12. doi: 10.1016/j.psychres.2009.09.006. Epub 2010 May 21. PMID: 20493557.


  • Shaira Urbano, Licensed Pharmacist

    Shaira is a licensed pharmacist (Bachelor of Pharmacy) and an experienced content writer. She enjoys inspiring and informing her readers through research-backed, comprehensive health content. Shaira draws from her personal experience working with real-life patients in a hospital setting and is currently pursuing her passion in writing.


Shaira is a licensed pharmacist (Bachelor of Pharmacy) and an experienced content writer. She enjoys inspiring and informing her readers through research-backed, comprehensive health content. Shaira draws from her personal experience working with real-life patients in a hospital setting and is currently pursuing her passion in writing.