Lumbrokinase, a unique enzyme derived from earthworms, has garnered attention in the world of health and wellness. Highly valued in traditional medicine, it’s now making strides in Western medicine due to its remarkable health benefits.
However, like any health supplement, understanding the health benefits of lumbrokinase and its side effects is crucial before incorporating it into your routine.
Table of Contents
What Is Lumbrokinase?
Lumbrokinase is a group of proteolytic enzymes, scientifically termed Eisenia Fetida Extract (EFE), originating from the Lumbricus rubellus earthworm. These enzymes collectively break down proteins, particularly those involved in blood clotting. [1]
What sets lumbrokinase apart is its specific action on fibrin, a protein critical to clotting. It degrades fibrin directly and activates plasmin, a natural fibrin-dissolving enzyme, maintaining healthy blood circulation and mitigating thrombotic diseases. [2]
Health Benefits of Lumbrokinase
The health benefits of lumbrokinase are both comprehensive and backed by a growing body of scientific research. Its potent enzymatic activity has multiple positive impacts on various aspects of health.
Promotes Cardiovascular Health
Lumbrokinase’s unique ability to break down fibrin, a key protein in blood clotting, directly supports heart health. By preventing potentially harmful clot formation, it fosters healthy blood circulation. [3]
Enhances Fibrinolytic Activity
The enzyme bolsters the body’s natural fibrinolytic activity, further mitigating the risk of blood clots and associated health conditions like stroke and heart attack. [4]
Helps Maintain Healthy Blood Pressure
Like Nattokinase, the health benefits of lumbrokinase are maintaining healthy blood pressure levels, further contributing to cardiovascular wellness, and preventing hypertensive complications. [5]
Anti-Inflammatory Properties
Lumbrokinase has notable anti-inflammatory properties. It can be beneficial in managing various inflammation-associated conditions, potentially offering pain relief and enhanced mobility. [6]
Neuroprotective Potential
Emerging research suggests lumbrokinase may offer neuroprotective benefits. While more studies are needed, it might play a role in managing neurodegenerative diseases, offering hope in the fight against conditions like Alzheimer’s and Parkinson’s. [7]
Assists in Thrombolytic Therapy
As an effective fibrin-dissolving agent, lumbrokinase could be beneficial as an adjunctive treatment in thrombolytic therapy, helping to break down existing clots and prevent clot-related complications. [8]
Lumbrokinase Side Effects
Set aside the health benefits of lumbrokinase, it’s essential to understand potential side effects. The enzyme complex is generally considered safe, but it may not suit everyone, like all supplements.
Potential Bleeding Risks
Given its potent fibrinolytic activity, lumbrokinase could increase the risk of bleeding. This risk is particularly significant for individuals with bleeding disorders or those taking anticoagulant medications.
Allergic Reactions
Although rare, some individuals may have an allergic reaction to lumbrokinase. Symptoms could range from mild skin rashes to severe reactions like anaphylaxis, requiring immediate medical attention.
Gastrointestinal Disturbances
Lumbrokinase may cause some gastrointestinal side effects, including nausea, diarrhea, or stomach cramps. While these symptoms are generally mild and transient, they can be uncomfortable.
Potential Drug Interactions
Like Kava-Kava, Lumbrokinase has the potential to interact with certain medications, particularly those affecting blood clotting. If you’re taking any medication, particularly blood thinners like warfarin or aspirin, discussing this with your healthcare provider before starting lumbrokinase is crucial.
What Is Lumbrokinase Used For?
With the unique health benefits of lumbrokinase, Lumbrokinase has many potential uses in health maintenance and disease management. Its benefits span from cardiovascular health to potential neuroprotection.
- Cardiovascular Health: By breaking down fibrin, lumbrokinase helps to prevent blood clot formation, supporting overall cardiovascular health.
- Healthy Blood Pressure: Regular lumbrokinase intake can contribute to maintaining a healthy blood pressure level.
- Inflammation Control: Its anti-inflammatory properties can potentially aid in managing various inflammation-associated conditions.
- Thrombolytic Therapy: Lumbrokinase’s effectiveness in dissolving fibrin may benefit thrombolytic therapy, helping break down existing blood clots.
- Neuroprotection: Emerging research suggests potential neuroprotective benefits of lumbrokinase, particularly in managing neurodegenerative diseases.
- Stroke Rehabilitation: Some studies indicate that lumbrokinase may assist in stroke rehabilitation, potentially aiding recovery.
- Wound Healing: One of the health benefits of lumbrokinase, Lumbrokinase may support healthy wound healing by breaking down excess fibrin.
- Cancer Therapy Support: Preliminary research suggests lumbrokinase might aid in cancer therapy by inhibiting cancer cell migration and invasion. [9]
- Chronic Rhinosinusitis: Lumbrokinase may help manage conditions like chronic rhinosinusitis due to its fibrinolytic and anti-inflammatory properties.
- Lyme Disease: Some practitioners suggest lumbrokinase as an adjunct treatment for Lyme disease, given its potential to break down biofilms, though more research is needed. [10]
As always, it’s crucial to consult with a healthcare provider before using lumbrokinase for any specific health condition or therapeutic purpose.
What Is The Correct Lumbrokinase Dosage For You?
The correct dosage of lumbrokinase can vary depending on several factors, including the individual’s age, health status, and the targeted health condition. It’s important to remember that lumbrokinase should always be used under the guidance of a healthcare professional to ensure safe and effective use.
For adults, the general dosage recommendation is often 20-30 mg, taken 2-3 times daily on an empty stomach. However, for specific health conditions, the dosage may be adjusted accordingly.
As for children, lumbrokinase is typically not recommended without direct supervision by a healthcare provider. For elderly individuals, it’s essential to consult with a healthcare provider to determine a safe and effective dose, considering potential health conditions and medication interactions.
Pregnant and breastfeeding women should avoid lumbrokinase unless advised otherwise by a healthcare provider.
Remember that any supplement, including lumbrokinase, should not replace any existing medical treatment or medication unless under professional medical advice. Regular monitoring and adjustments are crucial for safe and optimal use.
Bottomline
Lumbrokinase stands out in the health supplement landscape with its unique fibrinolytic properties and potential health benefits, including cardiovascular support, anti-inflammatory effects, and possible neuroprotection.
Despite the promising health benefits of lumbrokinase, it’s essential to approach lumbrokinase use with balance, considering potential side effects and necessary precautions. Always consult with a healthcare provider before starting or adjusting any supplement regimen.
FAQs
Disclaimer: This article is only a guide. It does not substitute the advice given by your healthcare professional. Before making any health-related decision, consult your healthcare professional.
Editorial References And Fact-Checking
- Nguyen, Q. T. T., Rhee, H., Kim, M., Lee, M. Y., & Lee, E. J. (2023). Lumbrokinase, a Fibrinolytic Enzyme, Prevents Intra-Abdominal Adhesion by Inhibiting the Migrative and Adhesive Activities of Fibroblast via Attenuation of the AP-1/ICAM-1 Signaling Pathway. BioMed Research International, 2023.
- Wang, K. Y., Tull, L., Cooper, E., Wang, N., & Liu, D. (2013). Recombinant protein production of earthworm lumbrokinase for potential antithrombotic application. Evidence-Based Complementary and Alternative Medicine, 2013.
- Wang, Y. H., Li, S. A., Huang, C. H., Su, H. H., Chen, Y. H., Chang, J. T., & Huang, S. S. (2018). Sirt1 activation by post-ischemic treatment with lumbrokinase protects against myocardial ischemia-reperfusion injury. Frontiers in pharmacology, 9, 636.
- Liu, H., Yang, J., Li, Y., Ma, Y., Wang, W., Zhong, W., … & Du, S. (2022). A Novel Fibrinolytic Protein From Pheretima vulgaris: Purification, Identification, Antithrombotic Evaluation, and Mechanisms Investigation. Frontiers in Molecular Biosciences, 8, 772419.
- Chen, H., McGowan, E. M., Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., … & Lin, Y. (2018). Nattokinase: a promising alternative in prevention and treatment of cardiovascular diseases. Biomarker insights, 13, 1177271918785130.
- Danarto, R., Heriyanto, D. S., Risan, M., & Yuri, P. (2019). Lumbrokinase effects on pro-and anti-apoptotic gene expression in Wistar rats with testicular torsion. Research and reports in urology, 249-254.
- Moon, B. C., & Kim, J. S. (2018). The potential of earthworm and its components as a therapeutic agent for neuronal damage. Journal of Biomedical and Translational Research, 19(3), 58-64.
- Altaf, F., Wu, S., & Kasim, V. (2021). Role of fibrinolytic enzymes in anti-thrombosis therapy. Frontiers in Molecular Biosciences, 8, 680397.
- Hu, B., Yan, Y., Tong, F., Xu, L., Zhu, J., Xu, G., & Shen, R. (2018). Lumbrokinase/paclitaxel nanoparticle complex: potential therapeutic applications in bladder cancer. International journal of nanomedicine, 3625-3640.
- Cooper, E. L. (2009). New enzyme complex isolated from earthworms is potent fibrinolytic. Focus, 1-5.
